K34c

Name: K34c
Brand: Tocris Bioscience
SKU: 5114

Tocris Bioscience, part of Bio-Techne | Catalog # 5114

Citations (34)

COA / SDS

Potent and selective α5β1 integrin inhibitor

Key Product Details

Description:	Potent and selective α5β1 integrin inhibitor
Chemical Name:	N-(2,6-Dimethylbenzoyl)-O-[3-(2-pyridinylamino)propyl]-L-tyrosine
Purity:	≥98% (HPLC)
Molecular Weight:	447.53

View Full Technical Details for K34c

Technical Data
Citations

Biological Activity for K34c

K34c is a potent and selective α5β1 integrin inhibitor (IC₅₀ = 3.1 nM). K34c inhibits cell survival and migration, inhibits p53-dependent senescence induced by Temozolomide (Cat. No. 2706) or Ellipticine (Cat. No. 3357) and promotes apoptosis in U87MG cells. K34c also prevents TGFβ-induced infiltration in vivo and reduces cell adhesion on fibronectin.

Technical Data for K34c

M. Wt	447.53
Formula	C₂₆H₂₉N₃O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	939769-93-4
PubChem ID	16663328
InChi Key	VLNHAQFIBARCQP-UHFFFAOYSA-N
Smiles	O=C(C3=C(C)C=CC=C3C)N[C@H](C(O)=O)CC(C=C2)=CC=C2OCCCNC1=CC=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for K34c

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	44.75	100
	ethanol	44.75	100

Preparing Stock Solutions for K34c

The following data is based on the product molecular weight 447.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.23 mL	11.17 mL	22.34 mL
5 mM	0.45 mL	2.23 mL	4.47 mL
10 mM	0.22 mL	1.12 mL	2.23 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

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References for K34c

References are publications that support the biological activity of the product.

Kuonen TGF-β, fibronectin and integrin α5β1 promote invasion in basal cell carcinoma. J.Invest.Dermatol. 2018 PMID: 29758283
Martinkova α5β1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cells. Int.J.Cancer 2010 PMID: 20099278
Renner Expression/activation of α5β1 integrin is linked to the β-catenin signaling pathway to drive migration in glioma cells. Oncotarget 2016 PMID: 27613837
Heckmann Probing integrin selectivity: rational design of highly active and selective ligands for the α5β1 and αvβ3 integrin receptor. Angew.Chem.Int.Ed.Engl 2007 PMID: 17394271