cis VH 298

Name: cis VH 298
Brand: Tocris Bioscience
SKU: 6157

Tocris Bioscience, part of Bio-Techne | Catalog # 6157

COA / SDS

Negative control for VH 298

Key Product Details

Description:	Negative control for VH 298
Chemical Name:	(2S,4S)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	523.65

View Full Technical Details for cis VH 298

Technical Data
Citations

Biological Activity for cis VH 298

cis VH 298 is a negative control for VH 298 (Cat.No. 6156). Exhibits no detectable binding of VHL.

Licensing Information

Sold under licence from the University of Dundee

Compound Libraries for cis VH 298

cis VH 298 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of VH 298 is reviewed on the chemical probes website.

Technical Data for cis VH 298

M. Wt	523.65
Formula	C₂₇H₃₃N₅O₄S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2097381-86-5
PubChem ID	127021044
InChi Key	NDVQUNZCNAMROD-JAXLGGSGSA-N
Smiles	O=C(N[C@@H](C(C)(C)C)C(N1C[C@H](C[C@H]1C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)O)=O)C4(C#N)CC4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for cis VH 298

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	52.37	100
	ethanol	52.37	100

Preparing Stock Solutions for cis VH 298

The following data is based on the product molecular weight 523.65.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.91 mL	9.55 mL	19.10 mL
5 mM	0.38 mL	1.91 mL	3.82 mL
10 mM	0.19 mL	0.95 mL	1.91 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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Reconstitution Calculator

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References for cis VH 298

References are publications that support the biological activity of the product.

Frost Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition. Nat.Commun. 2016 PMID: 27811928