QS 11

Name: QS 11
Brand: Tocris Bioscience
SKU: 3324

Tocris Bioscience, part of Bio-Techne | Catalog # 3324

Citations (3)

COA / SDS

ARFGAP1 inhibitor; modulates Wnt/β-catenin signaling

Key Product Details

Description:	ARFGAP1 inhibitor; modulates Wnt/β-catenin signaling
Chemical Name:	(2S)-2-[2-(Indan-5-yloxy)-9-(1,1'-biphenyl-4-yl)methyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol
Purity:	≥98% (HPLC)
Molecular Weight:	567.68

View Full Technical Details for QS 11

Technical Data
Citations

Biological Activity for QS 11

QS 11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also reduces in vitro migration of metastatic human breast cancer cells.

Compound Libraries for QS 11

QS 11 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for QS 11

M. Wt	567.68
Formula	C₃₆H₃₃N₅O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	944328-88-5
PubChem ID	42623900
InChi Key	DOKZLKDGUQWMSX-HKBQPEDESA-N
Smiles	OC[C@H](CC6=CC=CC=C6)NC1=C2C(N(CC3=CC=C(C7=CC=CC=C7)C=C3)C=N2)=NC(OC4=CC=C(CCC5)C5=C4)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for QS 11

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	56.77	100
	ethanol	56.77	100

Preparing Stock Solutions for QS 11

The following data is based on the product molecular weight 567.68.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.76 mL	8.81 mL	17.62 mL
5 mM	0.35 mL	1.76 mL	3.52 mL
10 mM	0.18 mL	0.88 mL	1.76 mL
50 mM	0.04 mL	0.18 mL	0.35 mL

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References for QS 11

References are publications that support the biological activity of the product.

Emre A chemical approach to stem cell biology Curr.Opin.Chem.Biol. 2007 PMID: 17493865
Zhang Small-molecule synergist of the Wnt/β-catenin signaling pathway. Proc.Natl.Acad.Sci.USA 2007 PMID: 17460038