SecinH3

Name: SecinH3
Brand: Tocris Bioscience
SKU: 2849

Tocris Bioscience, part of Bio-Techne | Catalog # 2849

Citations (23)

COA / SDS

Sec7-specific GEF inhibitor; selective for cytohesin family

Key Product Details

Description:	Sec7-specific GEF inhibitor; selective for cytohesin family
Chemical Name:	N-[4-[5-(1,3-Benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl]phenyl]-2-(phenylthio)acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	460.5

View Full Technical Details for SecinH3

Technical Data
Citations

Biological Activity for SecinH3

SecinH3 is a Sec7-specific GEF inhibitor that displays selectivity for small GEFs of the cytohesin family (IC₅₀ values are 2.4, 5.4, 5.4, 5.6, 5.6, 65 and > 100 μM for hCyh2, hCyh1, mCyh3, hCyh3, drosophila steppke, yGea2-S7 and hEFA6-S7 respectively). Inhibits insulin signaling via inhibition of insulin receptor substrate protein (IRS) phosphorylation.

Compound Libraries for SecinH3

SecinH3 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SecinH3

M. Wt	460.5
Formula	C₂₄H₂₀N₄O₄S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	853625-60-2
PubChem ID	1029232
InChi Key	QPGYAMIHXLCFTJ-UHFFFAOYSA-N
Smiles	O=C(CSC5=CC=CC=C5)NC(C=C4)=CC=C4N1C(C2=CC(OCO3)=C3C=C2)=NC(OC)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SecinH3

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	46.05	100

Preparing Stock Solutions for SecinH3

The following data is based on the product molecular weight 460.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.17 mL	10.86 mL	21.72 mL
5 mM	0.43 mL	2.17 mL	4.34 mL
10 mM	0.22 mL	1.09 mL	2.17 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

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References for SecinH3

References are publications that support the biological activity of the product.

Fuss The cytohesin Steppke is essential for Ins signalling in Drosophila. Nature 2006 PMID: 17167488
Hafner Inhibition of cytohesins by secinH3 leads to hepatic Ins resistance. Nature 2006 PMID: 17167487