tri-GalNAc biotin

Name: tri-GalNAc biotin
Brand: Tocris Bioscience
SKU: 7635

Tocris Bioscience, part of Bio-Techne | Catalog # 7635

COA / SDS

Biotinylated ASGPR ligand for LYTAC research and development

Key Product Details

Description:	Biotinylated ASGPR ligand for LYTAC research and development
Purity:	≥90% (HPLC)
Molecular Weight:	1916.21

View Full Technical Details for tri-GalNAc biotin

Technical Data
Citations

Biological Activity for tri-GalNAc biotin

Tri-GalNAc-biotin is a biotinylated asialoglycoprotein receptor (ASGPR) ligand for lysosomal targeting chimera (LYTAC) research and development, comprising a triantennary N-acetylgalactosamine (GalNAc) joined by a PEG linker to biotin. Tri-GalNAc-biotin can induce ASGPR-mediated endocytosis and trafficking of fluorescently labeled neutravidin for lysosomal degradation in HepG2 cells in a time-dependent manner. The increase in fluorescent signal within cells plateaus after 16-20h, and this effect can be inhibited by addition of tri-GalNAc COOH (Cat. No. 7401).

Technical Data for tri-GalNAc biotin

M. Wt	1916.21
Formula	C₈₃H₁₄₆N₁₄O₃₄S
Storage	Store at -20°C
Purity	≥90% (HPLC)
InChi Key	GFCCTIAQGWLOHY-PTYDYDFOSA-N
Smiles	O[C@@H]1[C@H](O)[C@@H](NC(C)=O)[C@H](OCCCCC(NCCCNC(CCOCC(NC(CCNC(CCOCCOCCOCCNC(CCCC[C@@H]2SC[C@@](N3)([H])[C@]2([H])NC3=O)=O)=O)=O)(COCCC(NCCCNC(CCCCO[C@@H]4O[C@H](CO)[C@H](O)[C@H](O)[C@H]4NC(C)=O)=O)=O)COCCC(NCCCNC(CCCCO[C@@H]5O[C@H](CO)[C@H](O)[C@H](O)[C@H]5NC(C)=O)=O)=O)=O)=O)O[C@@H]1CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for tri-GalNAc biotin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	95.81	50

Preparing Stock Solutions for tri-GalNAc biotin

The following data is based on the product molecular weight 1916.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	1.04 mL	5.22 mL	10.44 mL
2.5 mM	0.21 mL	1.04 mL	2.09 mL
5 mM	0.10 mL	0.52 mL	1.04 mL
25 mM	0.02 mL	0.10 mL	0.21 mL

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References for tri-GalNAc biotin

References are publications that support the biological activity of the product.

Zhou Development of triantennary N-acetylgalactosamine conjugates as degraders for extracellular proteins. ACS Cent.Sci. 2021 PMID: 33791431