IL-12: Proteins and Enzymes
IL-12 (Interleukin-12) is a heterodimeric cytokine that consists of a p35 and a p40 subunit. p40 is also a subunit of the cytokine IL-23. IL-12 enhances the cytotoxic activity and induces IFN-gamma production in NK cells, T cells, and dendritic epidermal T cells, and it promotes a Th1 biased immune response. It signals through a receptor complex composed of IL-12 R beta 1 and IL-12 R beta 2. Both homodimeric p40, and IL-23 can bind to the IL-12 receptor, serving as non-signaling antagonists.
11 results for "IL-12 Proteins and Enzymes" in Products
11 results for "IL-12 Proteins and Enzymes" in Products
IL-12: Proteins and Enzymes
IL-12 (Interleukin-12) is a heterodimeric cytokine that consists of a p35 and a p40 subunit. p40 is also a subunit of the cytokine IL-23. IL-12 enhances the cytotoxic activity and induces IFN-gamma production in NK cells, T cells, and dendritic epidermal T cells, and it promotes a Th1 biased immune response. It signals through a receptor complex composed of IL-12 R beta 1 and IL-12 R beta 2. Both homodimeric p40, and IL-23 can bind to the IL-12 receptor, serving as non-signaling antagonists.
GS Linker, Defined heterodimer stoichiometry.
| Source: | HEK293 |
| Accession #: | P29460.1 (IL-12p40), P29459.2 (IL-12p35) |
| Applications: | BA |
| Source: | Sf 21 (baculovirus) |
| Accession #: | NP_072133 (p40) & Q9R103 (p35) |
| Applications: | BA |
| Source: | Sf 21 (baculovirus) |
| Accession #: | P43432 (p40) & NP_032377 (p35) |
| Applications: | BA |
| Source: | CHO |
| Accession #: | Q28268 (p40) & Q28267 (p35) |
| Applications: | BA |
| Source: | Sf 21 (baculovirus) |
| Accession #: | O02744 (p40) & O02743 (p35) |
| Applications: | BA |
GS Linker, Defined heterodimer stoichiometry.
| Source: | HEK293 |
| Accession #: | NP_001274204 (IL-12p40) & XP_005546300 (IL-12p35) |
| Applications: | BA |
| Source: | CHO |
| Accession #: | Q28938 (p40) & Q29053 (p35) |
| Applications: | BA |
GS Linker, Defined heterodimer stoichiometry.
| Source: | NS0 |
| Accession #: | P43432, P43431 |
| Applications: | BA |
| Source: | CHO |
| Accession #: | P48095 (p40) & NP_001038199 (p35) |
| Applications: | BA |
| Source: | HEK293 |
| Accession #: | P29459.2 |
| Applications: | BA |
Analyzed by SEC-MALS
| Source: | Sf 21 (baculovirus) |
| Accession #: | P29460 (p40) & P29459 (p35) |
| Applications: | BA |