Tankyrase Inhibitors: Small Molecules and Peptides
Tankyrase 1, also known as TNKS, TANK1, and PARP5A, is a ubiquitously expressed member of the PARP family of proteins. Its ribosylation activity inhibits TRF1, a regulator of telomere length, leading to chromosomal lengthening. Tankyrase 1 also activates the Wnt signaling pathway by promoting Axin-1 and -2 degradation followed by beta-Catenin activation.
4 results for "Tankyrase Inhibitors Small Molecules and Peptides" in Products
4 results for "Tankyrase Inhibitors Small Molecules and Peptides" in Products
Tankyrase Inhibitors: Small Molecules and Peptides
Tankyrase 1, also known as TNKS, TANK1, and PARP5A, is a ubiquitously expressed member of the PARP family of proteins. Its ribosylation activity inhibits TRF1, a regulator of telomere length, leading to chromosomal lengthening. Tankyrase 1 also activates the Wnt signaling pathway by promoting Axin-1 and -2 degradation followed by beta-Catenin activation.
Potent tankyrase inhibitor
| Alternate Names: | XAV939 Wnt Signaling Inhibitor |
| Chemical Name: | 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one |
| Purity: | ≥98% (HPLC) |
Potent tankyrase inhibitor
| Chemical Name: | 2-[3-[[4-(4-Methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-1H-benz[de]isoquinoline-1,3(2H)-dione |
| Purity: | ≥98% (HPLC) |
XAV 939 synthesized to cGMP guidelines
| Chemical Name: | 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one |
| Purity: | ≥99% |
Potent TNKS1/2 inhibitor
| Chemical Name: | rel-2-[4-[6-[(3R,5S)-3,5-Dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-4H-pyrrolo[2,3-d]pyrimidin-4-one |
| Purity: | ≥98% (HPLC) |
