Apoptosis Inducer Compounds Products
Apoptosis inducers produce pro-apoptotic effects via different mechanisms. These include DNA cross-linking, inhibition of antiapoptotic proteins, and activation of caspases. These apoptosis inducers can target specific cellular processes to induce antitumor or antineoplastic effects.
34 results for "Apoptosis Inducer Compounds" in Products
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Apoptosis Inducer Compounds Products
Apoptosis inducers produce pro-apoptotic effects via different mechanisms. These include DNA cross-linking, inhibition of antiapoptotic proteins, and activation of caspases. These apoptosis inducers can target specific cellular processes to induce antitumor or antineoplastic effects.
34 results for "Apoptosis Inducer Compounds" in Products
DNA cross-linking antitumor agent
| Alternate Names: | Ametycine |
| Chemical Name: | [1aS-(1aα,8β,8aα,8bα)]-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione |
| Purity: | ≥98% (HPLC) |
Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis
| Chemical Name: | 1-[(3,4-Dichlorophenyl)methyl]-1H-indole-2,3-dione |
| Purity: | ≥99% (HPLC) |
Antitumor antibiotic agent. Inhibits DNA topoisomerase II
| Alternate Names: | Adriamycin,NSC 123127 |
| Chemical Name: | 10-[(3-Amino-2,3,6-trideoxy-α-L-lyxohexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-5,12-naphthacenedione hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent pro-apoptotic anticancer agent; activates caspase-3
| Alternate Names: | CDDP |
| Chemical Name: | cis-Diaminodichloroplatinum |
Inhibits RNA polymerase
| Chemical Name: | 2-Amino-(N,N)-1-bis(hexadecahydro-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1]-[1,4,7,10,13] oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide |
| Purity: | ≥95% (HPLC) |
DNA cross-linking antitumor agent
| Alternate Names: | Eloxatin |
| Chemical Name: | Oxalato[(1R-trans)-1,2-cyclohexanediamine]platinum(II) |
| Purity: | ≥99% (HPLC) |
Deoxyadenosine analog; pro-apoptotic
| Alternate Names: | 2-Chloro-2'-deoxyadenosine |
| Chemical Name: | (2R,3S,5R)-5-(6-Amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxalan-3-ol |
| Purity: | ≥99% (HPLC) |
DNA-methylating antitumor agent
| Alternate Names: | NSC 362856,CCRG 81045 |
| Chemical Name: | 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide |
| Purity: | ≥99% (HPLC) |
Potent and selective MEK inhibitor; orally bioavailable
| Chemical Name: | N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide |
| Purity: | ≥98% (HPLC) |
Alkylating agent; chemotherapeutic
| Chemical Name: | 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide |
| Purity: | ≥99% (HPLC) |
Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive
| Chemical Name: | (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one |
| Purity: | ≥98% (HPLC) |
Antitumor and anti-HIV agent; activates NF-κB. Also TGR5 agonist
| Chemical Name: | (+)-(3β)-3-Hydroxylup-20(29)-en-28-oic acid |
DNA cross-linking antitumor agent
| Alternate Names: | NSC 241240,Paraplatin,JM 8 |
| Chemical Name: | cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II) |
| Purity: | ≥99% (HPLC) |
Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines
| Chemical Name: | 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide |
| Purity: | ≥98% (HPLC) |
Selectively induces cancer cell apoptosis
| Chemical Name: | 2-[[3-(2,3-Dichlorophenoxy)propyl]amino]ethanol hydrochloride |
| Purity: | ≥99% (HPLC) |
DNA alkylator; antitumor and induces diabetes
| Alternate Names: | Streptozotocin |
| Chemical Name: | 2-Deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-D-glucose |
| Purity: | ≥95% (HPLC) |
Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter
| Alternate Names: | Kempferol |
| Chemical Name: | 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one |
| Purity: | ≥98% (HPLC) |
ULK inhibitor
| Chemical Name: | N-[3-[[5-Cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide dihydrochloride |
| Purity: | ≥98% (HPLC) |
Cytostatic agent; exhibits DNA alkylating and purine analog properties
| Chemical Name: | 5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent fatty acid synthase inhibitor; proapoptotic
| Alternate Names: | trans-C 75 |
| Chemical Name: | (2R*,3S*)-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic acid |
| Purity: | ≥95% (HPLC) |
High affinity Bcl-2 family inhibitor; proapoptotic, senolytic and antitumor
| Chemical Name: | 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide |
| Purity: | ≥98% (HPLC) |
Hypoxia-activated DNA alkylating agent prodrug
| Chemical Name: | (1-Methyl-2-nitro-1H-imidazol-5-yl)methyl N,N'-bis(2-bromoethyl)phosphorodiamidate |
| Applications: | AdAct |
| Purity: | ≥98% (HPLC) |
Stimulates RhoA activation; antiproliferative agent that slows cell cycle progression
| Chemical Name: | (2S,3R,4S,4aR)-3,4,4a,5-Tetrahydro-2,3,4,7-tetrahydroxy-(1,3)dioxolo(4,5-j)phenanthridin-6(2H)-one |
| Purity: | ≥98% (HPLC) |
