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Highly selective GSK-3 inhibitor; acts as Wnt activator
| Alternate Names: | CHIR99021,CT99021 |
| Chemical Name: | 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile |
| Purity: | ≥98% (HPLC) |
CHIR 99021 synthesized to cGMP guidelines
| Chemical Name: | 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile |
| Purity: | ≥99% |
Potent GSK-3β inhibitor
| Chemical Name: | 2-Methyl-5-[3-[4-(methylsulfinyl)phenyl]-5-benzofuranyl]-1,3,4-oxadiazole |
| Purity: | ≥99% (HPLC) |
Hydrochloride salt of CHIR 99021 (Cat. No. 4423); selective GSK-3 inhibitor
| Alternate Names: | CT99021 |
| Chemical Name: | 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile trihydrochloride |
| Purity: | ≥98% (HPLC) |
Potent, selective GSK-3 inhibitor
| Chemical Name: | 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione |
| Purity: | ≥98% (HPLC) |
Potent GSK3 inhibitor; induces neuronal and CD8(+) T cell differentiation
| Chemical Name: | 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol |
| Purity: | ≥97% (HPLC) |
Potent GSK-3 inhibitor; also inhibits cdks
| Alternate Names: | 6BIO |
| Chemical Name: | (2'Z,3'E)-6-Bromoindirubin-3'-oxime |
| Purity: | ≥98% (HPLC) |
GSK-3β inhibitor; also inhibits cdks
| Chemical Name: | 9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one |
| Purity: | ≥98% (HPLC) |
Potent, selective GSK-3 inhibitor
| Chemical Name: | 3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione |
| Purity: | ≥99% (HPLC) |
Selective GSK-3 inhibitor
| Chemical Name: | N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea |
| Purity: | ≥99% (HPLC) |
Highly potent, selective GSK-3 inhibitor
| Chemical Name: | 1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea |
| Purity: | ≥99% (HPLC) |
Selective non-ATP competitive inhibitor of GSK 3β
| Alternate Names: | NP 01139 |
| Chemical Name: | 2-Methyl-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione |
| Purity: | ≥98% (HPLC) |
Potent JAK3 inhibitor. Also inhibits GSK-3β and PKC
| Alternate Names: | NIBR3049 |
| Chemical Name: | 3-[5-[4-(2-Hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione |
| Purity: | ≥98% (HPLC) |
Potent and selective GSK-3β inhibitor
| Chemical Name: | N-(3-Chloro-4-methylphenyl)-5-(4-nitrophenyl)-1,3,4-oxadiazol-2-amine |
| Purity: | ≥98% (HPLC) |
Inactive analog of BIO (Cat. No. 3194)
| Chemical Name: | (2'Z,3'E)-6-Bromo-1-methylindirubin-3'-oxime |
| Purity: | ≥99% (HPLC) |
