GFR alpha-1/GDNF R alpha-1 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-77043

Novus Biologicals, part of Bio-Techne
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NBP1-77043-0.025mg
NBP1-77043
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Cited:

Mouse

Applications

ELISA, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all GFR alpha-1/GDNF R alpha-1 Antibodies »

Product Summary for GFR alpha-1/GDNF R alpha-1 Antibody - BSA Free

Immunogen

Antibody was raised against a 14 amino acid peptide near the center of human GFR alpha 1. The immunogen is located within amino acids 360 - 410 of GFR alpha 1. Amino Acid Squence: KNKPLGPAGSENEI

Specificity

GFR alpha 1 antibody is predicted to not cross-react with other members of the GFR alpha family of proteins.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

51 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for GFR alpha-1/GDNF R alpha-1 Antibody - BSA Free

Western Blot: GFR alpha-1/GDNF R alpha-1 Antibody [NBP1-77043] - Analysis of GFR alpha 1 in crude membrane fractions of human brain (B), liver (L), kidney (K), and spleen (S), respectively, with GFR alpha 1 antibody at 1 ug/mL
Immunocytochemistry/Immunofluorescence: GFR alpha-1/GDNF R alpha-1 Antibody [NBP1-77043] - Human brain tissue with GFR alpha 1 antibody at 20 ug/mL. Red: GFR alpha 1 Antibody Blue: DAPI stainin
Immunohistochemistry-Paraffin: GFR alpha-1/GDNF R alpha-1 Antibody [NBP1-77043] - Human brain tissue with GDNF Receptor alpha 1 antibody at 1 ug/ml.
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Applications for GFR alpha-1/GDNF R alpha-1 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/Immunofluorescence

20 ug/ml

Immunohistochemistry

1 ug/ml

Immunohistochemistry-Paraffin

1 ug/ml

Western Blot

1 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Ion exchange chromatography

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GFR alpha-1/GDNF R alpha-1

Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRalpha, which is a cell surface receptor for GDNF. The cDNAs encoding GDNFRalpha from human, rat, chicken and mouse have been cloned recently. GDNFRalpha was also termed Ret ligand 1 (RETL1) or TGF-beta-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRalpha-1 recently. GFRalpha-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFRalpha and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.

Long Name

Glial Cell line-derived Neurotrophic Factor Receptor alpha 1

Alternate Names

GDNF R alpha-1, GFR alpha1, GFRa-1, GFRA1

Gene Symbol

GFRA1

UniProt

P56159 (Human)

Additional GFR alpha-1/GDNF R alpha-1 Products

Product Documents for GFR alpha-1/GDNF R alpha-1 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for GFR alpha-1/GDNF R alpha-1 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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