Serum Amyloid P (SAP) is a non-fibrillar plasma glycoprotein that belongs to the pentraxin family. It is universally found in amyloid deposits and this is probably due to its specific calcium-dependent binding to motifs present on all types of amyloid fibrils. SAP is also found to prevent fibrillar breakdown by enzymes and it is believed that it helps maintains stability of the amyloid deposits (1,2). It has been shown that SAP binds monocytes with high avidity, but does not bind to erythrocytes, NK cells, T lymphocytes or B lymphocytes (3). SAP production can be induced by exposure to IL-1, IL-6 and IFN-beta. The SAP-inducing activity was neutralized by antibodies to each of the recombinant cytokines (4).

Long Name

Serum Amyloid P Component

Alternate Names

APCS, PTX2, SAP

Gene Symbol

APCS

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Product Documents for Pentraxin 2/SAP Antibody (APCS/3240) [Janelia Fluor® 646]

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Product Specific Notices for Pentraxin 2/SAP Antibody (APCS/3240) [Janelia Fluor® 646]

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Pentraxin 2/SAP Antibody (APCS/3240) [Janelia Fluor® 646]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-79848JF646

Key Product Details

Species Reactivity

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Product Specifications

Immunogen

Localization

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Applications for Pentraxin 2/SAP Antibody (APCS/3240) [Janelia Fluor® 646]

Immunohistochemistry

Immunohistochemistry-Paraffin

Protein Array

Formulation, Preparation, and Storage

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Background: Pentraxin 2/SAP