Abacavir hemisulfate

Name: Abacavir hemisulfate
Brand: Tocris Bioscience
SKU: 4148

Tocris Bioscience, part of Bio-Techne | Catalog # 4148

Citations (2)

COA / SDS

Reverse transcriptase inhibitor; antiretroviral

Discontinued Product

4148 has been discontinued. View all RNA/DNA Polymerase Inhibitors products.

Key Product Details

Description:	Reverse transcriptase inhibitor; antiretroviral
Chemical Name:	(1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol hemisulfate
Purity:	≥99% (HPLC)
Molecular Weight:	335.37

View Full Technical Details for Abacavir hemisulfate

Technical Data
Citations

Biological Activity for Abacavir hemisulfate

Abacavir hemisulfate is a competitive reverse transcriptase inhibitor; inhibits HIV replication. Orally active and brain penetrant. Antiretroviral agent.

Licensing Information

Sold for research purposes under agreement from Viiv.

Compound Libraries for Abacavir hemisulfate

Abacavir hemisulfate is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Abacavir hemisulfate

M. Wt	335.37
Formula	C₁₄H₁₈N₆O.½H₂SO₄
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	188062-50-2
PubChem ID	75539558
InChi Key	WMHSRBZIJNQHKT-NHMRBCHTSA-N
Smiles	OS(O)(=O)=O.NC1=NC(NC2CC2)=C2N=CN(C3C[C@H](CO)C=C3)C2=N1.NC1=NC(NC2CC2)=C2N=CN(C3C[C@H](CO)C=C3)C2=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Abacavir hemisulfate

References are publications that support the biological activity of the product.

Harrigan Resistance profile of the human immunodeficiency virus type 1 reverse transcriptase inhibitor aba. (1592U89) after monotherapy and combination therapy. CNA2001 Investigative Group. J.Infect.Dis. 2000 PMID: 10720512
Daluge 1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity. Antimicrob Agents Chemother. 1997 PMID: 9145874
Charneira N-terminal valine adduct from the anti-HIV drug aba. in rat haemoglobin as evidence for aba. metabolism to a reactive aldehyde in vivo. Br.J.Pharmacol. 2012 PMID: 22725138