AR-C 66096 tetrasodium salt

Name: AR-C 66096 tetrasodium salt
Brand: Tocris Bioscience
SKU: 3321

Tocris Bioscience, part of Bio-Techne | Catalog # 3321

Citations (13)

COA / SDS

Potent and selective P2Y12 antagonist

Discontinued Product

3321 has been discontinued. View all P2Y Receptor Antagonists products.

Key Product Details

Description:	Potent and selective P2Y₁₂ antagonist
Alternative Names:	FPL 66096,ARL 66096
Chemical Name:	2-(Propylthio)adenosine-5'-O-(β,γ-difluoromethylene)triphosphate tetrasodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	703.26

View Full Technical Details for AR-C 66096 tetrasodium salt

Technical Data
Citations

Biological Activity for AR-C 66096 tetrasodium salt

AR-C 66096 tetrasodium salt is a potent and selective P2Y₁₂ receptor antagonist. Blocks ADP-induced inhibition of adenylyl cyclase in vitro (pK_B =7.6) and inhibits ADP-induced aggregation of washed human platelets (pIC₅₀ = 8.16).

Licensing Information

Sold for research purposes under agreement from AstraZeneca

Technical Data for AR-C 66096 tetrasodium salt

M. Wt	703.26
Formula	C₁₄H₁₈F₂N₅Na₄O₁₂P₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	145782-74-7
PubChem ID	90488830
InChi Key	IETVOLFQZIGNAQ-HVYRMSERSA-J
Smiles	[Na+].[Na+].[Na+].[Na+].CCCSC1=NC(N)=C2N=CN([C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)C(F)(F)P([O-])([O-])=O)[C@@H](O)[C@H]3O)C2=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for AR-C 66096 tetrasodium salt

References are publications that support the biological activity of the product.

Ingall Antagonists of the platelet P receptor: a novel approach to antithrombotic therapy. J.Med.Chem. 1999 PMID: 9925726
Simon Activity of adenosine diphosphates and triphosphates on a P2YT-type receptor in brain capillary endothelial cells. Br.J.Pharmacol. 2001 PMID: 11156575
Humphries FPL 66096: a novel, highly potent and selective antagonist at human platelet P2T-purinoceptors. Br.J.Pharmacol. 1994 PMID: 7858849