aTAG 2139

Name: aTAG 2139
Brand: Tocris Bioscience
SKU: 6970

Tocris Bioscience, part of Bio-Techne | Catalog # 6970

Citations (1)

COA / SDS

Degrader of MTH1 fusion proteins for use within the aTAG system

Key Product Details

Description:	Degrader of MTH1 fusion proteins for use within the aTAG system
Alternative Names:	CFT 2139
Chemical Name:	6-(6-((4-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)carbamoyl)pyridin-3-yl)-N-methyl-4-(phenylamino)quinoline-3-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	782.81

View Full Technical Details for aTAG 2139

Technical Data
Citations

Biological Activity for aTAG 2139

aTAG 2139 is a degrader of MTH1 fusion proteins for use within the aTAG system. Comprises a ligand selective for MTH1, a linker and the cereblon-binding ligand Thalidomide (Cat. No. 0652). Induces highly potent and selective degradation of fusion proteins after a 4 h incubation (DC₅₀ = 0.27 nM; D_max = 92.1%). Cell-permeable. Suitable for in vitro and in vivo applications.

Negative control aTAG 2139-NEG (Cat. No. 7575) also available.

Mouse DMPK properties are provided in the supplementary file (see below).

MTH1 can be expressed as a fusion with a target protein of interest using genome engineering techniques via CRISPR-mediated locus-specific knock-in. See protocol for more information.

Licensing Information

Sold under exclusive license from C4 Therapeutics

Supplementary Information

Mouse DMPK properties are provided in the accompanying supplementary file.

Technical Data for aTAG 2139

M. Wt	782.81
Formula	C₄₂H₃₈N₈O₈
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2387510-81-6
InChi Key	IKLCDLVLZPLJRR-UHFFFAOYSA-N
Smiles	O=C(CCC1N2C(C3=C(C(OCC(NCCCCNC(C4=CC=C(C5=CC=C(N=CC(C(NC)=O)=C6NC7=CC=CC=C7)C6=C5)C=N4)=O)=O)=CC=C3)C2=O)=O)NC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for aTAG 2139

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	39.14	50

Preparing Stock Solutions for aTAG 2139

The following data is based on the product molecular weight 782.81.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	2.55 mL	12.77 mL	25.55 mL
2.5 mM	0.51 mL	2.55 mL	5.11 mL
5 mM	0.26 mL	1.28 mL	2.55 mL
25 mM	0.05 mL	0.26 mL	0.51 mL

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References for aTAG 2139

References are publications that support the biological activity of the product.

Veits Development of an AchillesTAG degradation system and its application to control CAR-T activity. Curr.Res.Chem.Biol.