AZ 6102

Name: AZ 6102
Brand: Tocris Bioscience
SKU: 5775

Tocris Bioscience, part of Bio-Techne | Catalog # 5775

COA / SDS

Potent TNKS1/2 inhibitor

Key Product Details

Description:	Potent TNKS1/2 inhibitor
Chemical Name:	rel-2-[4-[6-[(3R,5S)-3,5-Dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-4H-pyrrolo[2,3-d]pyrimidin-4-one
Purity:	≥98% (HPLC)
Molecular Weight:	428.53

View Full Technical Details for AZ 6102

Technical Data
Citations

Biological Activity for AZ 6102

AZ 6102 is a potent TNKS2 and TNKS1 inhibitor (IC₅₀ values are 1 and 3 nM, respectively). Exhibits >100-fold selectivity for TNKS1/2 over PARP-1, PARP-2 and PARP-6. Inhibits Wnt signaling in DLD-1 cells (IC₅₀ = 5 nM). Exhibits moderate oral bioavailability.

Compound Libraries for AZ 6102

AZ 6102 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of AZ6102 is reviewed on the chemical probes website.

Technical Data for AZ 6102

M. Wt	428.53
Formula	C₂₅H₂₈N₆O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1645286-75-4
PubChem ID	91663328
InChi Key	WCPTUQOMNJBIET-CALCHBBNSA-N
Smiles	CC1=CC(N2C[C@H](C)N[C@H](C)C2)=NC=C1C3=CC=C(C(N4)=NC5=C(C=CN5C)C4=O)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AZ 6102

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	21.43	50

Preparing Stock Solutions for AZ 6102

The following data is based on the product molecular weight 428.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.67 mL	23.34 mL	46.67 mL
2.5 mM	0.93 mL	4.67 mL	9.33 mL
5 mM	0.47 mL	2.33 mL	4.67 mL
25 mM	0.09 mL	0.47 mL	0.93 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for AZ 6102

References are publications that support the biological activity of the product.

Johannes Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacology. ACS Med.Chem.Lett. 2015 PMID: 25815142