AZD 1283

Name: AZD 1283
Brand: Tocris Bioscience
SKU: 6085

Tocris Bioscience, part of Bio-Techne | Catalog # 6085

Citations (3)

COA / SDS

High affinity P2Y12 antagonist

Key Product Details

Description:	High affinity P2Y₁₂ antagonist
Chemical Name:	Ethyl 5-cyano-2-methyl-6-[4-[[[(phenylmethyl)sulfonyl]amino]carbonyl]-1-piperidinyl]-3-pyridinecarboxylate
Purity:	≥98% (HPLC)
Molecular Weight:	470.54

View Full Technical Details for AZD 1283

Technical Data
Citations

Biological Activity for AZD 1283

AZD 1283 is a potent and high affinity P2Y₁₂ antagonist (IC₅₀ = 11 nM in radioligand competition binding assay, and 25 nM in a GTPγS binding assay). Causes a dose-dependent increase in blood flow and inhibits ADP-induced platelet aggregation in vivo. Antithrombotic.

Compound Libraries for AZD 1283

AZD 1283 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AZD 1283

M. Wt	470.54
Formula	C₂₃H₂₆N₄O₅S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	919351-41-0
PubChem ID	23649325
InChi Key	NEMHKCNXXRQYRF-UHFFFAOYSA-N
Smiles	CCOC(C1=CC(C#N)=C(N2CCC(C(NS(=O)(CC3=CC=CC=C3)=O)=O)CC2)N=C1C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AZD 1283

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	47.05	100

Preparing Stock Solutions for AZD 1283

The following data is based on the product molecular weight 470.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.13 mL	10.63 mL	21.25 mL
5 mM	0.43 mL	2.13 mL	4.25 mL
10 mM	0.21 mL	1.06 mL	2.13 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

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References for AZD 1283

References are publications that support the biological activity of the product.

Zhang Agonist-bound structure of the human P2Y₁₂ receptor. Nature 2014 PMID: 24784220
Zhang Structure of the human P2Y₁₂ receptor in complex with an antithrombotic drug. Nature 2014 PMID: 24670650
Bach Lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the P2Y₁₂ receptor. separation of the antithrombotic effect and bleeding for candidate drug AZD1283. J.Med.Chem. 2013 PMID: 23899349