Azidothymidine

Name: Azidothymidine
Brand: Tocris Bioscience
SKU: 4150

Tocris Bioscience, part of Bio-Techne | Catalog # 4150

Citations (6)

COA / SDS

Selective reverse transcriptase inhibitor; antiretroviral

Discontinued Product

4150 has been discontinued. View all RNA/DNA Polymerase Inhibitors products.

Key Product Details

Description:	Selective reverse transcriptase inhibitor; antiretroviral
Chemical Name:	3'-Azido-3'-deoxythymidine
Purity:	≥99% (HPLC)
Molecular Weight:	267.24

View Full Technical Details for Azidothymidine

Technical Data
Citations

Biological Activity for Azidothymidine

Azidothymidine is a selective reverse transcriptase inhibitor. Exhibits 100-fold selectivity for HIV reverse transcriptase over DNA polymerase α. Suppresses HIV-1 replication and enhances cell viability in HIV-1 infected T cells. Attenuates growth of multiple myeloma (MM) cells in vitro and reduces growth of MM tumor xenografts in mice. Increases differentiation iPSCs into cortical neurons and reduces the over-proliferation of neural precursors. Orally bioavailable and brain penetrant. Antiretroviral agent. Also decreases CRISPR-mediated homology directed repair (HDR) efficiency.

Licensing Information

Sold for research purposes under agreement from Viiv.

Technical Data for Azidothymidine

M. Wt	267.24
Formula	C₁₀H₁₃N₅O₄
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	30516-87-1
PubChem ID	35370
InChi Key	HBOMLICNUCNMMY-XLPZGREQSA-N
Smiles	O=C1N([C@@H]2O[C@H](CO)[C@@H](N=[N+]=[N-])C2)C=C(C)C(N1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Azidothymidine

References are publications that support the biological activity of the product.

Hu The telomerase inhibitor AZT enhances differentiation and prevents overgrowth of human pluripotent stem cell-derived neural progenitors. J.Biol.Chem. 2018 PMID: 29628445
Yu Small molecules enhance CRISPR genome editing in pluripotent stem cells. Cell Stem Cell 2015 PMID: 25658371
Pereira Azidothymidine is effective against human multiple myeloma: a new use for an old drug? Anticancer Agents Med.Chem. 2013 PMID: 22931421
Broder The development of antiretroviral therapy and its impact on the HIV-1/AIDS pandemic. Antiviral Res. 2010 PMID: 20018391
Furman Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase. Proc.Natl.Acad.Sci.U.S.A. 1986 PMID: 2430286
Mitsuya 3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro. Proc.Natl.Acad.Sci.U.S.A. 1985 PMID: 2413459

Product Documents for Azidothymidine

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Zidovudine (AZT), which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov