BRD 73954

Name: BRD 73954
Brand: Tocris Bioscience
SKU: 6284

Tocris Bioscience, part of Bio-Techne | Catalog # 6284

COA / SDS

Dual histone deacetylase (HDAC) 6/8 inhibitor

Key Product Details

Description:	Dual histone deacetylase (HDAC) 6/8 inhibitor
Chemical Name:	N¹-Hydroxy-N³-(2-phenylethyl)-1,3-benzenedicarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	284.31

View Full Technical Details for BRD 73954

Technical Data
Citations

Biological Activity for BRD 73954

BRD 73954 is a dual histone deacetylase (HDAC) 6/8 inhibitor. IC₅₀ values are 0.036 μM, 0.12 μM, 9 μM, >33 μM, for HDAC6, HDAC8, HDAC2 and HDAC4, respectively.

Compound Libraries for BRD 73954

BRD 73954 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BRD 73954

M. Wt	284.31
Formula	C₁₆H₁₆N₂O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1440209-96-0
PubChem ID	71680913
InChi Key	FIHKWEQJEDRIFS-UHFFFAOYSA-N
Smiles	ONC(C1=CC=CC(C(NCCC2=CC=CC=C2)=O)=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BRD 73954

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	28.43	100
	ethanol	5.69	20 with gentle warming

Preparing Stock Solutions for BRD 73954

The following data is based on the product molecular weight 284.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.52 mL	17.59 mL	35.17 mL
5 mM	0.70 mL	3.52 mL	7.03 mL
10 mM	0.35 mL	1.76 mL	3.52 mL
50 mM	0.07 mL	0.35 mL	0.70 mL

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Reconstitution Calculator

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References for BRD 73954

References are publications that support the biological activity of the product.

Olson Discovery of the first histone deacetylase 6/8 dual inhibitors. J.Med.Chem. 2013 PMID: 23672185