CCT 018159

Name: CCT 018159
Brand: Tocris Bioscience
SKU: 2435

Tocris Bioscience, part of Bio-Techne | Catalog # 2435

Citations (3)

COA / SDS

Hsp90 inhibitor

Key Product Details

Description:	Hsp90 inhibitor
Chemical Name:	4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]-6-ethyl-1,3-benzenediol
Purity:	≥98% (HPLC)
Molecular Weight:	352.39

View Full Technical Details for CCT 018159

Technical Data
Citations

Biological Activity for CCT 018159

CCT 018159 is a novel inhibitor of heat shock protein 90 (Hsp90) ATPase activity (IC₅₀ = 5.7 μM) that displays selectivity over human Hsp72 and topoisomerase II. Inhibits proliferation of HCT116 human colon tumor cells and produces upregulation of Hsp70 and downregulation of c-Raf and cdk4. More soluble than 17-AAG (Cat. No. 1515) and is independent of NQO1/DT-diaphorase and P-glycoprotein expression.

Technical Data for CCT 018159

M. Wt	352.39
Formula	C₂₀H₂₀N₂O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	171009-07-7
PubChem ID	5327091
InChi Key	BBTMGPQSLSYPHE-ZHZULCJRSA-N
Smiles	CCC1=C(O)C=C(O)C(=C1)C1=NNC(C)=C1C1=CC2=C(OCCO2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CCT 018159

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	35.24	100

Preparing Stock Solutions for CCT 018159

The following data is based on the product molecular weight 352.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.84 mL	14.19 mL	28.38 mL
5 mM	0.57 mL	2.84 mL	5.68 mL
10 mM	0.28 mL	1.42 mL	2.84 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

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References for CCT 018159

References are publications that support the biological activity of the product.

Dymock Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design. J.Med.Chem. 2005 PMID: 15974572
Sharp In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors. Cancer Res. 2007 PMID: 17332351
Cheung The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors. Bioorg.Med.Chem.Lett. 2005 PMID: 15955698