CEP 1347

Name: CEP 1347
Brand: Tocris Bioscience
SKU: 4924

Tocris Bioscience, part of Bio-Techne | Catalog # 4924

Citations (16)

COA / SDS

Inhibitor of JNK signaling

Key Product Details

Description:	Inhibitor of JNK signaling
Chemical Name:	(9S,10R,12R)-5-16-Bis[(ethylthio)methyl]-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester
Purity:	≥97% (HPLC)
Molecular Weight:	615.76

View Full Technical Details for CEP 1347

Technical Data
Citations

Biological Activity for CEP 1347

CEP 1347 is a potent inhibitor of mixed lineage kinases MLK3, MLK1 and MLK2 (IC₅₀ values in vitro are 23-39 nM, 38-61 nM and 51-82 nM, respectively), and blocks downstream c-jun N-terminal kinase (JNK) activation (IC₅₀ = 20 nM). CEP 1347 rescues motor neurons undergoing apoptosis (EC₅₀ = 20 nM), blocks Aβ-induced cortical neuron apoptosis (EC₅₀ ~51 nM) and, in an animal model of Huntington's disease, restores BDNF mRNA to wild type levels. CEP 1347 is also a MDM4 inhibitor. It displays inhibition of malignant meningioma cells growth in vitro, and shows anti-tumor activity in a mouse xenograft model of meningioma in vivo. CEP 1347 is orally bioavailable and brain penetrant.

Technical Data for CEP 1347

M. Wt	615.76
Formula	C₃₃H₃₃N₃O₅S₂
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	156177-65-0
PubChem ID	9917013
InChi Key	SCMLRESZJCKCTC-KMYQRJGFSA-N
Smiles	O=C(NC8)C1=C8C(C(C=C(CSCC)C=C7)=C7N45)=C4C2=C1C6=C(C=CC(CSCC)=C6)N2[C@H]3C[C@](O)([C@](OC)=O)[C@]5(C)O3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CEP 1347

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	6.16	10

Preparing Stock Solutions for CEP 1347

The following data is based on the product molecular weight 615.76.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.24 mL	81.20 mL	162.40 mL
0.5 mM	3.25 mL	16.24 mL	32.48 mL
1 mM	1.62 mL	8.12 mL	16.24 mL
5 mM	0.32 mL	1.62 mL	3.25 mL

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References for CEP 1347

References are publications that support the biological activity of the product.

Mitobe The novel MDM4 inhibitor CEP-1347 activates the p53 pathway and blocks malignant meningioma growth in vitro and in vivo. Biomedicines 2023 PMID: 11071967
Maroney Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family. J.Biol.Chem. 2001 PMID: 11325962
Conforti Blood level of brain-derived neurotrophic factor mRNA is progressively reduced in rodent models of Huntington's disease: Restoration by the neuroprotective compound CEP-1347. Mol.Cell.Neurosci. 2008 PMID: 18571429
Saporito Preservation of cholinergic activity and prevention of neuron death by CEP-1347/KT-7515 following excitotoxic injury of the nucleus basalis magnocellularis. Neuroscience 1998 PMID: 9881861
Bozyczko-Coyne CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis. J.Neurochem. 2001 PMID: 11331414
Maroney Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway. J.Neurosci. 1998 PMID: 9412490