CG 858-Neg

Name: CG 858-Neg
Brand: Tocris Bioscience
SKU: 7428

Tocris Bioscience, part of Bio-Techne | Catalog # 7428

COA / SDS

Negative control for CG 858 (Cat. No. 7427)

Key Product Details

Description:	Negative control for CG 858 (Cat. No. 7427)
Chemical Name:	N-[[4-[3-[2,6-Difluoro-3-[(propylsulfonyl)amino]benzoyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]phenyl]methyl]-5-[[2-(1-methyl-2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]pentanamide
Purity:	≥98% (HPLC)
Molecular Weight:	853.9

View Full Technical Details for CG 858-Neg

Technical Data
Citations

Biological Activity for CG 858-Neg

Negative control for CG 858 (Cat. No. 7427)

Licensing Information

Sold under license from Cullgen

Technical Data for CG 858-Neg

M. Wt	853.9
Formula	C₄₃H₄₁F₂N₇O₈S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2417296-83-2
PubChem ID	155520701
InChi Key	KMSYZOWKSVQANC-UHFFFAOYSA-N
Smiles	CCCS(=O)(NC1=CC=C(C(C(C2=CNC3=NC=C(C4=CC=C(C=C4)CNC(CCCCNC5=CC=C6C(N(C(C6=C5)=O)C7CCC(N(C)C7=O)=O)=O)=O)C=C23)=O)=C1F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CG 858-Neg

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	85.39	100

Preparing Stock Solutions for CG 858-Neg

The following data is based on the product molecular weight 853.9.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.17 mL	5.86 mL	11.71 mL
5 mM	0.23 mL	1.17 mL	2.34 mL
10 mM	0.12 mL	0.59 mL	1.17 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Reconstitution Calculator

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References for CG 858-Neg

References are publications that support the biological activity of the product.

Han Discovery of selective small molecule degraders of BRAF-V600E. J.Med.Chem. 2020 PMID: 32223235