cis MZ 1

Name: cis MZ 1
Brand: Tocris Bioscience
SKU: 6155

Tocris Bioscience, part of Bio-Techne | Catalog # 6155

Citations (2)

COA / SDS

Negative Control for MZ 1 (Cat. No. 6154)

Key Product Details

Description:	Negative Control for MZ 1 (Cat. No. 6154)
Chemical Name:	(2S,4S)-1-((S)-2-(tert-butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)- 4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	1002.64

View Full Technical Details for cis MZ 1

Technical Data
Citations

Biological Activity for cis MZ 1

cis MZ 1 is a negative Control for MZ1 (Cat.No. 6154). Exhibits no significant VHL binding affinity.

Licensing Information

Sold under licence from the University of Dundee

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of MZ 1 is reviewed on the chemical probes website.

Technical Data for cis MZ 1

M. Wt	1002.64
Formula	C₄₉H₆₀ClN₉O₈S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1797406-72-4
PubChem ID	124201820
InChi Key	PTAMRJLIOCHJMQ-HADAFJFFSA-N
Smiles	CC1=C(C2=C(N3C(C)=NN=C3[C@@H](N=C2C4=CC=C(C=C4)Cl)CC(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N5C[C@H](C[C@H]5C(NCC6=CC=C(C7=C(N=CS7)C)C=C6)=O)O)=O)=O)=O)S1)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for cis MZ 1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	100.26	100
	ethanol	100.26	100

Preparing Stock Solutions for cis MZ 1

The following data is based on the product molecular weight 1002.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.00 mL	4.99 mL	9.97 mL
5 mM	0.20 mL	1.00 mL	1.99 mL
10 mM	0.10 mL	0.50 mL	1.00 mL
50 mM	0.02 mL	0.10 mL	0.20 mL

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References for cis MZ 1

References are publications that support the biological activity of the product.

Zengerle Selective small molecule induced degradation of the BET bromodomain protein BRD4. ACS.Chem.Biol. 2015 PMID: 26035625