Cyclic Pifithrin-α hydrobromide

Name: Cyclic Pifithrin-α hydrobromide
Brand: Tocris Bioscience
SKU: 3843

Tocris Bioscience, part of Bio-Techne | Catalog # 3843

Citations (2)

COA / SDS

p53 inhibitor

Key Product Details

Description:	p53 inhibitor
Alternative Names:	Pifithrin-β
Chemical Name:	5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazole hydrobromide
Purity:	≥98% (HPLC)
Molecular Weight:	349.29

View Full Technical Details for Cyclic Pifithrin-α hydrobromide

Technical Data
Citations

Biological Activity for Cyclic Pifithrin-α hydrobromide

Cyclic Pifithrin-α hydrobromide is a cyclic analog of pifithrin-α (Cat. No. 1267), a small molecule inhibitor of p53. Prevents dexamethasone-induced cell death in murine thymocytes (EC₅₀ = 2.01 μM). Sensitizes p53-deficient tumors to radiotherapy and chemotherapy; increases apoptosis in target cells when used in combination with antimicrotubule agents.

Compound Libraries for Cyclic Pifithrin-α hydrobromide

Cyclic Pifithrin-α hydrobromide is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for Cyclic Pifithrin-α hydrobromide

M. Wt	349.29
Formula	C₁₆H₁₆N₂S.HBr
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	511296-88-1
PubChem ID	11515812
InChi Key	SGNCOAOESGSEOP-UHFFFAOYSA-N
Smiles	CC(C=C4)=CC=C4C1=CN(C2=C(S3)CCCC2)C3=N1.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cyclic Pifithrin-α hydrobromide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	34.93	100

Preparing Stock Solutions for Cyclic Pifithrin-α hydrobromide

The following data is based on the product molecular weight 349.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.86 mL	14.31 mL	28.63 mL
5 mM	0.57 mL	2.86 mL	5.73 mL
10 mM	0.29 mL	1.43 mL	2.86 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

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References for Cyclic Pifithrin-α hydrobromide

References are publications that support the biological activity of the product.

Pietrancosta Novel cyclized Pifithrin-alpha p53 inactivators: synthesis and biological studies. Bioorg.Med.Chem.Lett. 2005 PMID: 15745797
Zuco and Zunino Cyclic Pifithrin-α sensitizes wild type p53 tumor cells to antimicrotubule agent-induced apoptosis. Neoplasia 2008 PMID: 18516295
Barchechath Inhibitors of apoptosis in lymphocytes: synthesis and biological evaluation of compounds related to pifithrin-α. J.Med.Chem. 2005 PMID: 16190767