Daptomycin

Name: Daptomycin
Brand: Tocris Bioscience
SKU: 3917

Tocris Bioscience, part of Bio-Techne | Catalog # 3917

Citations (8)

COA / SDS

Antibiotic; inhibits protein, DNA and RNA synthesis in gram-positive bacteria

Key Product Details

Description:	Antibiotic; inhibits protein, DNA and RNA synthesis in gram-positive bacteria
Alternative Names:	LY 146032
Chemical Name:	N-(1-Oxodecyl)-L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithinyl-L-α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl-(3R)-3-methyl-L-α-glutamyl-α,2-diamino-γ-oxo-benzene butanoic acid (13-4) lactone
Purity:	≥95% (HPLC)
Molecular Weight:	1620.67

View Full Technical Details for Daptomycin

Technical Data
Citations

Biological Activity for Daptomycin

Daptomycin is a lipopeptide, calcium-dependent antibiotic. Exhibits potent bacteriocidal activity against most gram-positive bacteria in vitro and in vivo, including antibiotic-resistant strains such as MRSA and VRE. Disrupts plasma membrane function; activity results in membrane depolarization leading to inhibition of protein, DNA and RNA synthesis.

Technical Data for Daptomycin

M. Wt	1620.67
Formula	C₇₂H₁₀₁N₁₇O₂₆
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	103060-53-3
PubChem ID	16129629
InChi Key	DOAKLVKFURWEDJ-OFNKPWESSA-N
Smiles	O=C(N[C@@H](CCCN)C(N[C@@H](CC(O)=O)C(N[C@H](C)C4=O)=O)=O)CN[C@]([C@H]([C@H](OC([C@@H](NC([C@@H](NC([C@@H](CO)NC(CNC([C@@H](N4)CC(O)=O)=O)=O)=O)[C@@H](C)CC(O)=O)=O)CC(C3=CC=CC=C3N)=O)=O)C)NC([C@H](CC(O)=O)NC([C@@H](CC(N)=O)NC([C@H](CC1=CNC2=C1C=CC=C2)NC(CCCCCCCCC)=O)=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Daptomycin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	162.07	100
	water	32.41	20

Preparing Stock Solutions for Daptomycin

The following data is based on the product molecular weight 1620.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.62 mL	3.09 mL	6.17 mL
5 mM	0.12 mL	0.62 mL	1.23 mL
10 mM	0.06 mL	0.31 mL	0.62 mL
50 mM	0.01 mL	0.06 mL	0.12 mL

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References for Daptomycin

References are publications that support the biological activity of the product.

Robbel and Marahiel Daptomycin, a bacterial lipopeptide synthesized by a non-ribosomal machinery. J.Biol.Chem. 2010 PMID: 20522545
Jung Structural transitions as determinants of the action of the calcium-dependent antibiotic dapto. Chem.Biol. 2004 PMID: 15271353
Steenbergen Daptomycin: a lipopeptide antibiotic for the treatment of serious gram-positive infections. J.Antimicrob Chemother. 2005 PMID: 15705644
Tally and DeBruin Development of dapto. for gram-positive infections. J.Antimicrob Chemother. 2000 PMID: 11020247