E 7820

Name: E 7820
Brand: Tocris Bioscience
SKU: 6785

Tocris Bioscience, part of Bio-Techne | Catalog # 6785

COA / SDS

α2 integrin inhibitor; anti-angiogenic

Key Product Details

Description:	α₂ integrin inhibitor; anti-angiogenic
Chemical Name:	3-Cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	336.37

View Full Technical Details for E 7820

Technical Data
Citations

Biological Activity for E 7820

E 7820 is a α₂ integrin inhibitor. Inhibits angiogenesis in vitro (IC₅₀ = 0.11 - 0.25 μM). Also inhibits growth of human colorectal cancer cell lines. Enhances efficacy of erlotinib in a non-small-cell lung cancer xenograft model. Also acts as a molecular glue to induce proteosomal degradation of mRNA splicing factor RBM39.

Compound Libraries for E 7820

E 7820 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for E 7820

M. Wt	336.37
Formula	C₁₇H₁₂N₄O₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	289483-69-8
PubChem ID	196970
InChi Key	LWGUASZLXHYWIV-UHFFFAOYSA-N
Smiles	CC1=C2C(C#N)=CNC2=C(C=C1)NS(=O)(C3=CC(C#N)=CC=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for E 7820

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	33.64	100

Preparing Stock Solutions for E 7820

The following data is based on the product molecular weight 336.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.97 mL	14.86 mL	29.73 mL
5 mM	0.59 mL	2.97 mL	5.95 mL
10 mM	0.30 mL	1.49 mL	2.97 mL
50 mM	0.06 mL	0.30 mL	0.59 mL

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References for E 7820

References are publications that support the biological activity of the product.

Ito Enhanced anti-angiogenic effect of E7820 in combination with erlotinib in epidermal growth factor receptor-tyrosine kinase inhibitor-resistant non-small-cell lung cancer xenograft models. Cancer Sci. 2014 PMID: 24841832
Uehara Selective degradation of splicing factor CAPERα by anticancer sulfonamides. Nat.Chem.Biol. 2017 PMID: 28437394
Funahashi Sulfonamide derivative, E7820, is a unique angiogenesis inhibitor suppressing an expression of integrin α2 subunit on endothelium. Cancer Res.