EIDD 1931

Name: EIDD 1931
Brand: Tocris Bioscience
SKU: 7231

Tocris Bioscience, part of Bio-Techne | Catalog # 7231

COA / SDS

Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral nucleoside

Key Product Details

Description:	Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral nucleoside
Chemical Name:	N-Hydroxycytidine
Purity:	≥98% (HPLC)
Molecular Weight:	259.22

View Full Technical Details for EIDD 1931

Technical Data
Citations

Biological Activity for EIDD 1931

EIDD 1931 is a viral RNA-dependent RNA polymerase (RdRP) inhibitor and broad spectrum antiviral nucleotide. Inhibits replication of a range of RNA viruses including influenza, Ebola, HCV, and human and zoonotic coronaviruses (IC₅₀ values are 0.15 and 0.3 μM for inhibition of MERS-CoV and SARS-CoV-2 replication in vitro). Increases mutation rates and induces lethal mutagenesis in viral RNA. Also inhibits replication of mouse hepatitis virus with mutations conferring resistance to remdesivir (Cat. No. 7226).

Compound Libraries for EIDD 1931

EIDD 1931 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for EIDD 1931

M. Wt	259.22
Formula	C₉H₁₃N₃O₆
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	3258-02-4
PubChem ID	197020
InChi Key	XCUAIINAJCDIPM-XVFCMESISA-N
Smiles	OC[C@H]1O[C@@H](N2C=C/C(NC2=O)=N\O)[C@@H]([C@@H]1O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for EIDD 1931

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	25.92	100
	water	12.96	50

Preparing Stock Solutions for EIDD 1931

The following data is based on the product molecular weight 259.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.86 mL	19.29 mL	38.58 mL
5 mM	0.77 mL	3.86 mL	7.72 mL
10 mM	0.39 mL	1.93 mL	3.86 mL
50 mM	0.08 mL	0.39 mL	0.77 mL

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Reconstitution Calculator

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References for EIDD 1931

References are publications that support the biological activity of the product.

Sheahan An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sci.Transl.Med. 2020 PMID: 32253226
Urakova β-d-N⁴-hydroxycytidine is a potent anti-alphavirus compound that induces a high level of mutations in the viral genome. J.Virol. 2018 PMID: 29167335