EM 12-FS

Name: EM 12-FS
Brand: Tocris Bioscience
SKU: 7851

Tocris Bioscience, part of Bio-Techne | Catalog # 7851

COA / SDS

Molecular glue; induces degradation of NQAT1

Key Product Details

Description:	Molecular glue; induces degradation of NQAT1
Alternative Names:	Selective NTAQ1 degrader
Chemical Name:	3-[6-[(Fluorosulfonyl)oxy]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione
Purity:	≥95% (HPLC)
Molecular Weight:	342.3

View Full Technical Details for EM 12-FS

Technical Data
Citations

Biological Activity for EM 12-FS

EM12-FS is a selective N-terminal glutamine amidohydrolase 1 (NTAQ1) Degrader. In MOLT4 cells, it downregulates NTAQ1 via cereblon-mediated degradation (IC₅₀ = 256 nM). Requires covalent His353 engagement to recruit and degrade NTAQ1.

Technical Data for EM 12-FS

M. Wt	342.3
Formula	C₁₃H₁₁FN₂O₆S
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2839138-44-0
PubChem ID	165879822
InChi Key	RXYXBYLQECASPH-UHFFFAOYSA-N
Smiles	O=C1NC(C(CC1)N2C(C3=CC(OS(=O)(F)=O)=CC=C3C2)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for EM 12-FS

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	34.23	100

Preparing Stock Solutions for EM 12-FS

The following data is based on the product molecular weight 342.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.92 mL	14.61 mL	29.21 mL
5 mM	0.58 mL	2.92 mL	5.84 mL
10 mM	0.29 mL	1.46 mL	2.92 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

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References for EM 12-FS

References are publications that support the biological activity of the product.

Cruite Cereblon covalent modulation through structure-based design of histidine targeting chemical probes. RSC Chem.Biol. 2022 PMID: 36128501