Entecavir

Name: Entecavir
Brand: Tocris Bioscience
SKU: 6234

Tocris Bioscience, part of Bio-Techne | Catalog # 6234

COA / SDS

Potent and selective hepatitis B virus inhibitor

Key Product Details

Description:	Potent and selective hepatitis B virus inhibitor
Alternative Names:	BMS 200475,SQ 34676
Chemical Name:	2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one
Purity:	≥98% (HPLC)
Molecular Weight:	277.28

View Full Technical Details for Entecavir

Technical Data
Citations

Biological Activity for Entecavir

Entecavir is a potent and selective hepatitis B virus reverse transcriptase inhibitor (EC₅₀ = 3 nM); guanine analog. Inhibits hepatitis B virus replication in HepG2.2.15 cells. Displays selectively over HCMV, HSV-1, VZV, HIV and influenza (EC₅₀ values are 15, 32, 30-60, >10 and >80 μM respectively). Orally bioavailable.

Compound Libraries for Entecavir

Entecavir is also offered as part of the Tocriscreen Epigenetics Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Entecavir

M. Wt	277.28
Formula	C₁₂H₁₅N₅O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	142217-69-4
PubChem ID	153941
InChi Key	QDGZDCVAUDNJFG-FXQIFTODSA-N
Smiles	O=C1C2=C(N([C@H]3C[C@H](O)[C@@H](CO)C3=C)C=N2)NC(N)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Entecavir

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	27.73	100

Preparing Stock Solutions for Entecavir

The following data is based on the product molecular weight 277.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.61 mL	18.03 mL	36.06 mL
5 mM	0.72 mL	3.61 mL	7.21 mL
10 mM	0.36 mL	1.80 mL	3.61 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

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Reconstitution Calculator

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References for Entecavir

References are publications that support the biological activity of the product.

Bisacchi BMS-200475, a novel carbocyclic 2'-deoxyguanosine analog with potent and selective anti-hepatitis B virus activity in vitro Bioorganic &amp; Medicinal Chemistry Letters
Innaimo Identification of BMS-200475 as a potent and selective inhibitor of hepatitis B virus. Antimicrob. Agents Chemother. 1997 PMID: 9210663