Galidesivir dihydrochloride

Name: Galidesivir dihydrochloride
Brand: Tocris Bioscience
SKU: 7229

Tocris Bioscience, part of Bio-Techne | Catalog # 7229

COA / SDS

Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral

Key Product Details

Description:	Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral
Alternative Names:	BCX 4430
Chemical Name:	(2S,3S,4R,5R)-2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3,4-pyrrolidinediol dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	338.19

View Full Technical Details for Galidesivir dihydrochloride

Technical Data
Citations

Biological Activity for Galidesivir dihydrochloride

Galidesivir is a viral RNA-dependent RNA polymerase (RdRP) inhibitor and broad spectrum antiviral nucleotide. In vitro, galidesivir displays antiviral activity against a range of RNA viruses, including bunyaviruses, arenaviruses, paramyxoviruses, coronaviruses, and flaviviruses (EC₅₀ values range from 3 μM to >100 μM). Galidesivir protects against Ebola and Marburg viral infection in animal models.

Technical Data for Galidesivir dihydrochloride

M. Wt	338.19
Formula	C₁₁H₁₅N₅O₃.2HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1373208-51-5
PubChem ID	90008271
InChi Key	LOHGEHBUEDUIRK-PUSSMWDMSA-N
Smiles	NC1=NC=NC2=C1NC=C2[C@@H]3N[C@@H]([C@H]([C@H]3O)O)CO.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Galidesivir dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	33.82	100
	DMSO	16.91	50

Preparing Stock Solutions for Galidesivir dihydrochloride

The following data is based on the product molecular weight 338.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.96 mL	14.78 mL	29.57 mL
5 mM	0.59 mL	2.96 mL	5.91 mL
10 mM	0.30 mL	1.48 mL	2.96 mL
50 mM	0.06 mL	0.30 mL	0.59 mL

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Reconstitution Calculator

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References for Galidesivir dihydrochloride

References are publications that support the biological activity of the product.

Warren Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430. Nature. 2014 PMID: 24590073
Li & De Clercq Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nat.Rev.Drug Discov. 2020 PMID: 32127666