Gedunin

Name: Gedunin
Brand: Tocris Bioscience
SKU: 3387
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3387

(1)

Citations (13)

COA / SDS

Hsp90 inhibitor; exhibits anticancer and antimalarial activity

Key Product Details

Description:	Hsp90 inhibitor; exhibits anticancer and antimalarial activity
Chemical Name:	(1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)-5-(Acetyloxy)-1-(3-furanyl)-1,5,6,6a,7,10a,10b,11,12,12a,decahydro-4b,7,7,10a,12a,-pentamethyloxireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione
Purity:	≥98% (HPLC)
Molecular Weight:	482.57

View Full Technical Details for Gedunin

Technical Data
Citations / Reviews (1)

Biological Activity for Gedunin

Gedunin is a naturally occurring Hsp90 inhibitor. Induces Hsp90-dependent client protein degradation and displays antiproliferative activity in vitro (IC₅₀ values are 3.22, 8.84 and 16.8 μM in SKBr3, MCF-7 and CaCo-2 cancer cell lines respectively). Decreases ovarian cancer cell proliferation in vitro and may enhance cisplatin-induced reduction in proliferation (CAT.No 3387). Also exhibits antimalarial activity against Plasmodium falciparum (IC₅₀ values are 0.14 and 3.1 μM in parasite development and [³H]-hypoxanthine uptake assays respectively).

Technical Data for Gedunin

M. Wt	482.57
Formula	C₂₈H₃₄O₇
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	2753-30-2
PubChem ID	12004512
InChi Key	YJXDGWUNRYLINJ-BHAPSIHVSA-N
Smiles	O=C4[C@@H]6[C@]3(O6)[C@]2(C)[C@H](OC(C)=O)C[C@@]1([H])C(C)(C)C(C=C[C@@](C)1[C@]([H])2CC[C@](C)3[C@H]([C@]5=COC=C5)O4)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Gedunin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	48.26	100
	ethanol	4.83	10 with gentle warming

Preparing Stock Solutions for Gedunin

The following data is based on the product molecular weight 482.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.07 mL	10.36 mL	20.72 mL
5 mM	0.41 mL	2.07 mL	4.14 mL
10 mM	0.21 mL	1.04 mL	2.07 mL
50 mM	0.04 mL	0.21 mL	0.41 mL

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References for Gedunin

References are publications that support the biological activity of the product.

Kamath Gedunin, a novel natural substance, inhibits ovarian cancer cell proliferation. Int J Gynecol Cancer. 2009 PMID: 19955938
Brandt Gedunin, a novel Hsp90 inhibitor: semisynthesis of derivatives and preliminary structure-activity relationships. J.Med.Chem. 2008 PMID: 18816111
Lee Antimalarial activity of anthothecol derived from Khaya anthotheca (Meliaceae). Phytomedicine 2008 PMID: 17913482
Uddin Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo-2 colon cancer cell line in vitro. Phytother.Res. 2007 PMID: 17450509