Geldanamycin

Name: Geldanamycin
Brand: Tocris Bioscience
SKU: 1368
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1368

(2)

Citations (28)

COA / SDS

Selective Hsp90 inhibitor

Key Product Details

Description:	Selective Hsp90 inhibitor
Chemical Name:	9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate
Purity:	≥98% (HPLC)
Molecular Weight:	560.64

View Full Technical Details for Geldanamycin

Technical Data
Citations / Reviews (2)

Biological Activity for Geldanamycin

Geldanamycin is a selectively inhibits heat shock protein 90 (Hsp90). Binds to the ATP site of Hsp90 (K_d = 1.2 μM) and inhibits its chaperone activity. Consequently inhibits activities of oncogenic kinases (e.g. src, Raf), p53 and steroid receptors. Demonstrates antiproliferative effect on breast cancer stem-like cells.

Technical Data for Geldanamycin

M. Wt	560.64
Formula	C₂₉H₄₀N₂O₉
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	30562-34-6
PubChem ID	13017912
InChi Key	QTQAWLPCGQOSGP-PHLMVCJGSA-N
Smiles	O=C1C(OC)=C(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C/C=C(C)/C2=O)C(C(N2)=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Geldanamycin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	5.61	10

Preparing Stock Solutions for Geldanamycin

The following data is based on the product molecular weight 560.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.84 mL	89.18 mL	178.37 mL
0.5 mM	3.57 mL	17.84 mL	35.67 mL
1 mM	1.78 mL	8.92 mL	17.84 mL
5 mM	0.36 mL	1.78 mL	3.57 mL

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References for Geldanamycin

References are publications that support the biological activity of the product.

Lee Inhibition of heat shock protein (Hsp) 27 potentiates the suppressive effect of Hsp90 inhibitors in targeting breast cancer stem-like cells. Biochimie. 2012 PMID: 22445681
Roe Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanomycin. J.Med.Chem. 1999 PMID: 9925731
Whitesell Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation. Proc.Natl.Acad.Sci.U.S.A. 1994 PMID: 8078881
Cardenas Signal-transduction cascades as targets for therapeutic intervention by natural products. Trends Biotechnol. 1998 PMID: 9807840