ISOX DUAL

Name: ISOX DUAL
Brand: Tocris Bioscience
SKU: 5806

Tocris Bioscience, part of Bio-Techne | Catalog # 5806

COA / SDS

Dual BRD4 and CBP/p300 bromodomain inhibitor

Discontinued Product

5806 has been discontinued. View all Bromodomain Inhibitors products.

Key Product Details

Description:	Dual BRD4 and CBP/p300 bromodomain inhibitor
Chemical Name:	[3-[4-[2-[5-(Dimethyl-1,2-oxazol-4-yl)-1-[2-(morpholin-4-yl)ethyl]-1H-1,3-benzodiazol-2-yl]ethyl]phenoxy]propyl]dimethylamine
Purity:	≥98% (HPLC)
Molecular Weight:	531.69

View Full Technical Details for ISOX DUAL

Technical Data
Citations

Biological Activity for ISOX DUAL

ISOX DUAL is a dual CBP/p300 and BRD4 bromodomain inhibitor (IC₅₀ values are 0.65 and 1.5 μM for CBP and BRD4 respectively). Downregulates IL-6, IL-1β and IFN-β in macrophages.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for ISOX DUAL

M. Wt	531.69
Formula	C₃₁H₄₁N₅O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1962928-22-8
PubChem ID	121237857
InChi Key	HCDQWCDANVEBQR-UHFFFAOYSA-N
Smiles	CC(ON=C1C)=C1C2=CC(N=C(CCC3=CC=C(OCCCN(C)C)C=C3)N4CCN5CCOCC5)=C4C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for ISOX DUAL

References are publications that support the biological activity of the product.

Chekler Transcriptional profiling of a selective CREB binding protein bromodomain inhibitor highlights therapeutic opportunities. Chem.Biol. 2015 PMID: 26670081