Linezolid

Name: Linezolid
Brand: Tocris Bioscience
SKU: 3765
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3765

(2)

Citations (1)

COA / SDS

Antibiotic; inhibits protein synthesis in gram-positive bacteria

Key Product Details

Description:	Antibiotic; inhibits protein synthesis in gram-positive bacteria
Alternative Names:	PNU 100766,U 100766
Chemical Name:	N-[[(5S)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide
Purity:	≥99% (HPLC)
Molecular Weight:	337.35

View Full Technical Details for Linezolid

Technical Data
Citations / Reviews (2)

Biological Activity for Linezolid

Linezolid is an oxazolidinone antibiotic. Inhibits bacterial protein synthesis prior to chain initiation. Displays potent antibacterial activity against a variety of multidrug-resistant gram-positive microbes in vitro and in vivo. Identified as targeting human host cell proteins that interact with SARS-CoV-2.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for Linezolid

Linezolid is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Linezolid

M. Wt	337.35
Formula	C₁₆H₂₀FN₃O₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	165800-03-3
PubChem ID	441401
InChi Key	TYZROVQLWOKYKF-ZDUSSCGKSA-N
Smiles	FC1=CC(N3C[C@H](CNC(C)=O)OC3=O)=CC=C1N2CCOCC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Linezolid

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	33.74	100
	ethanol	8.43	25

Preparing Stock Solutions for Linezolid

The following data is based on the product molecular weight 337.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.96 mL	14.82 mL	29.64 mL
5 mM	0.59 mL	2.96 mL	5.93 mL
10 mM	0.30 mL	1.48 mL	2.96 mL
50 mM	0.06 mL	0.30 mL	0.59 mL

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Reconstitution Calculator

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References for Linezolid

References are publications that support the biological activity of the product.

Gordon A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing. Nature 2020 PMID: 32353859
Ford In vivo activities of U-100592 and U-100766, novel oxazolidinone antimicrobial agents, against experimental bacterial infections. Antimicrob.Agents Chemother. 1996 PMID: 8726028
Brickner Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections. J.Med.Chem. 2008 PMID: 18338841
Brickner Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multi-drug-resistant gram-positive bacterial infections. J.Med.Chem. 1996 PMID: 8576909