Mithramycin A

Name: Mithramycin A
Brand: Tocris Bioscience
SKU: 1489
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1489

(1)

Citations (20)

COA / SDS

Inhibitor of DNA and RNA polymerase

Key Product Details

Description:	Inhibitor of DNA and RNA polymerase
Chemical Name:	(1S)-5-Deoxy-1-C-[(2S,3S)-7-[[2,6-dideoxy-3-O-(2,6-dideoxy-β-D-arabino-hexopyranosyl)-β-D-arabino-hexopyranosyl]oxy]-3-[(O-2,6-dideoxy-3-C-methyl-β-D-ribo-hexopyranosyl-(1.fwdarw.3)-O-2,6-dideoxy-β-D-lyxo-hexopyranosyl-(1.fwdarw.3)-2,6-dideoxy-β-D-arabino-hexopyranosyl)oxy]-1,2,3,4-tetrahydro-5,10-dihydroxy-6-methyl-4-oxo-2-anthracenyl]-1-O-methyl-D-threo-2-pentulose
Purity:	≥95% (HPLC)
Molecular Weight:	1085.16

View Full Technical Details for Mithramycin A

Technical Data
Citations / Reviews (1)

Biological Activity for Mithramycin A

Mithramycin A is an anticancer antibiotic that selectively binds to G-C-rich DNA in the presence of Mg²⁺ or Zn²⁺, inhibiting RNA and DNA polymerase action. Inhibits c-myc expression and induces myeloid differentiation of HL-60 promyelocytic leukemia cells.

Technical Data for Mithramycin A

M. Wt	1085.16
Formula	C₅₂H₇₆O₂₄
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	18378-89-7
PubChem ID	90479798
InChi Key	CFCUWKMKBJTWLW-YZCDWGPJSA-N
Smiles	OC1=C2C(C=C3C(C([C@@H](OC5OC(C)C(O)C(OC6OC(C)C(O)C(OC7OC(C)C(O)C(O)(C)C7)C6)C5)[C@@]([C@H](OC)C([C@@H](O)[C@H](O)C)=O)([H])C3)=O)=C2O)=CC(O[C@@H]4OC(C)C(O)C(OC8OC(C)C(O)C(O)C8)C4)=C1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Mithramycin A

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	54.26	50

Preparing Stock Solutions for Mithramycin A

The following data is based on the product molecular weight 1085.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	1.84 mL	9.22 mL	18.43 mL
2.5 mM	0.37 mL	1.84 mL	3.69 mL
5 mM	0.18 mL	0.92 mL	1.84 mL
25 mM	0.04 mL	0.18 mL	0.37 mL

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Reconstitution Calculator

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References for Mithramycin A

References are publications that support the biological activity of the product.

Miller Mithramycin selectively inhibits transcription of G-C containing DNA. Am.J.Med.Sci. 1987 PMID: 2962490
Ray Mithramycin selectively inhibits the transcriptional activity of a transfected human c-myc gene. Am.J.Med.Sci. 1990 PMID: 2147360
Demicheli and Garnier-Suillerot Mithramycin cannot bind to left-handed poly(dG-m5dC) in the presence of Mg²⁺ ion. Biochem.Biophys.Res.Commun. 1991 PMID: 1828342

Product Documents for Mithramycin A

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Plicamycin, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov