ML 347

Name: ML 347
Brand: Tocris Bioscience
SKU: 4945

Tocris Bioscience, part of Bio-Techne | Catalog # 4945

Citations (3)

COA / SDS

Potent and selective ALK1 and ALK2 inhibitor

Key Product Details

Description:	Potent and selective ALK1 and ALK2 inhibitor
Alternative Names:	LDN 193719,1lWY,VU0469381
Chemical Name:	5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
Purity:	≥98% (HPLC)
Molecular Weight:	352.39

View Full Technical Details for ML 347

Technical Data
Citations

Biological Activity for ML 347

ML 347 is a potent and selective ALK2 and ALK1 inhibitor (IC₅₀ values are 32 and 46 nM, respectively); displays >200 fold selectivity over ALK3 and ALK6 and >400 fold selectivity over VEGF2. Exhibits no activity at ALK4, ALK5 or in a panel of related kinases. Inhibits BMP4 signaling in a functional assay (IC₅₀ = 152 nM).

Compound Libraries for ML 347

ML 347 is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for ML 347

M. Wt	352.39
Formula	C₂₂H₁₆N₄O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1062368-49-3
PubChem ID	44577753
InChi Key	FVRYPYDPKSZGNS-UHFFFAOYSA-N
Smiles	COC(C=C3)=CC=C3C(C=N2)=CN1C2=C(C4=CC=CC5=C4C=CC=N5)C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ML 347

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	7.05	20

Preparing Stock Solutions for ML 347

The following data is based on the product molecular weight 352.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	14.19 mL	70.94 mL	141.89 mL
1 mM	2.84 mL	14.19 mL	28.38 mL
2 mM	1.42 mL	7.09 mL	14.19 mL
10 mM	0.28 mL	1.42 mL	2.84 mL

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References for ML 347

References are publications that support the biological activity of the product.

Engers Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN Bioorg Med Chem Lett. 2013 PMID: 23639540