MS 436

Name: MS 436
Brand: Tocris Bioscience
SKU: 5173

Tocris Bioscience, part of Bio-Techne | Catalog # 5173

COA / SDS

Potent and selective BRD4(1) inhibitor

Discontinued Product

5173 has been discontinued. View all Bromodomain Inhibitors products.

Key Product Details

Description:	Potent and selective BRD4(1) inhibitor
Chemical Name:	(E)-4-[2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	383.42

View Full Technical Details for MS 436

Technical Data
Citations

Biological Activity for MS 436

MS 436 is a potent and selective BRD4 bromodomain inhibitor (K_i = 30 - 50 nM for the first bromodomain (BRD4(1)). Exhibits 10-fold selectivity for BRD4(1) over BRD4(2). Blocks BRD4 transcriptional activity in lipopolysaccharide-induced production of both nitric oxide and IL-6 in mouse macrophages (IC₅₀ values are 3.8 and 4.9 μM, respectively). Attenuates melanoma cell proliferation in vitro.

Licensing Information

Sold under license from Icahn School of Medicine at Mount Sinai.

Technical Data for MS 436

M. Wt	383.42
Formula	C₁₈H₁₇N₅O₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1395084-25-9
PubChem ID	60171585
InChi Key	BBJDRANVVNBXAR-JWGURIENSA-N
Smiles	NC1=C(/N=N/C2=CC=C(S(NC3=NC=CC=C3)(=O)=O)C=C2)C=C(C)C(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for MS 436

References are publications that support the biological activity of the product.

Segura BRD4 sustains melanoma proliferation and represents a new target for epigenetic therapy. Cancer Res. 2013 PMID: 23950209
Zhang Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains. J.Med.Chem. 2013 PMID: 24144283