NCT 02

Name: NCT 02
Brand: Tocris Bioscience
SKU: 7551

Tocris Bioscience, part of Bio-Techne | Catalog # 7551

COA / SDS

Molecular glue; induces degradation of CCNK and CDK12

Key Product Details

Description:	Molecular glue; induces degradation of CCNK and CDK12
Chemical Name:	6,7-Dihydro-N-(5-methyl-2-thiazolyl)-5H-indeno[5,6-b]furan-3-acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	312.39

View Full Technical Details for NCT 02

Technical Data
Citations

Biological Activity for NCT 02

NCT 02 acts as a molecular glue that induces proteasomal degradation of CCNK and CDK12 in colorectal cancer spheroid cells in vitro (IC₅₀ ≤ 50 μM). NCT 02 also induces apoptosis and the downregulation of genes involved in DNA damage repair.

Technical Data for NCT 02

M. Wt	312.39
Formula	C₁₇H₁₆N₂O₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	790245-61-3
PubChem ID	2501755
InChi Key	IELCYEUTXLYDOV-UHFFFAOYSA-N
Smiles	CC1=CN=C(S1)NC(CC2=COC3=C2C=C4CCCC4=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NCT 02

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	31.24	100

Preparing Stock Solutions for NCT 02

The following data is based on the product molecular weight 312.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.20 mL	16.01 mL	32.01 mL
5 mM	0.64 mL	3.20 mL	6.40 mL
10 mM	0.32 mL	1.60 mL	3.20 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for NCT 02

References are publications that support the biological activity of the product.

Dieter Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer. Cell Rep. 2021 PMID: 34289372