Pomalidomide

Name: Pomalidomide
Brand: Tocris Bioscience
SKU: 6302

Tocris Bioscience, part of Bio-Techne | Catalog # 6302

Citations (1)

COA / SDS

Cereblon binder; also TNF-α inhibitor and antiangiogenic

Key Product Details

Description:	Cereblon binder; also TNF-α inhibitor and antiangiogenic
Chemical Name:	4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity:	≥98% (HPLC)
Molecular Weight:	273.24

View Full Technical Details for Pomalidomide

Technical Data
Citations

Biological Activity for Pomalidomide

Pomalidomide is a potent TNF-α inhibitor (IC₅₀ = 13 nM). Also potently inhibits IL-2 (EC₅₀ = 8 nM). Thalidomide derivative. Binds cereblon and inhibits its ubiquitination. Exhibits antiproliferative effects in a Namalwa lymphoma cell line. Antiangiogenic. Promotes degradation of transcription factor SALL4.

Technical Data for Pomalidomide

M. Wt	273.24
Formula	C₁₃H₁₁N₃O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	19171-19-8
PubChem ID	134780
InChi Key	UVSMNLNDYGZFPF-UHFFFAOYSA-N
Smiles	NC1=CC=CC2=C1C(N(C2=O)C3CCC(NC3=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Pomalidomide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	27.32	100

Preparing Stock Solutions for Pomalidomide

The following data is based on the product molecular weight 273.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.66 mL	18.30 mL	36.60 mL
5 mM	0.73 mL	3.66 mL	7.32 mL
10 mM	0.37 mL	1.83 mL	3.66 mL
50 mM	0.07 mL	0.37 mL	0.73 mL

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References for Pomalidomide

References are publications that support the biological activity of the product.

Chamberlain Evolution of cereblon-mediated protein degradation as a therapeutic modality. ACS Med.Chem.Lett. 2019 PMID: 31857833
Donovan Thal. promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome. Elife 2018 PMID: 30067223
Winter Phthalimide conjugation as a strategy for in vivo target protein degradation. Science. 2015 PMID: 25999370
Lai Modular PROTAC design for the degradation of oncogenic BCR-ABL. Angew.Chem.Int.Ed.Engl. 2016 PMID: 26593377
Nanthakumar Dissecting fibrosis: therapeutic insights from the small-molecule toolbox. Nat.Rev.Drug.Discov. 2015 PMID: 26338155
Lohbeck & Miller Practical synthesis of a phthalimide-based Cereblon ligand to enable PROTAC development. Bioorg.Med.Chem.Lett. 2016 PMID: 27687673