Ribavirin

Name: Ribavirin
Brand: Tocris Bioscience
SKU: 4501

Tocris Bioscience, part of Bio-Techne | Catalog # 4501

Citations (3)

COA / SDS

Blocks eIF4E activity; antiviral guanosine analog

Key Product Details

Description:	Blocks eIF4E activity; antiviral guanosine analog
Chemical Name:	1-β-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide
Purity:	≥99% (HPLC)
Molecular Weight:	244.2

View Full Technical Details for Ribavirin

Technical Data
Citations

Biological Activity for Ribavirin

Ribavirin is an antiviral guanosine ribonucleoside analog; misincorporated into mRNA by viral-dependent RNA polymerases. Binds to and redistributes mammalian eIF4E from the nucleus to the cytoplasm (K_i ~ 0.3 μM for the active metabolite, ribavirin triphosphate). Also inosine monophosphate dehydrogenase (IMPDH) inhibitor. Represses colony formation of primary AML-M5 progenitor cells (IC₅₀ ~ 1 μM); reduces disease severity in acute myeloid leukemia (AML). Inhibits cytopathic effect of SARS-CoV in Vero cells in vitro. Orally available.

Compound Libraries for Ribavirin

Ribavirin is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Ribavirin

M. Wt	244.2
Formula	C₈H₁₂N₄O₅
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	36791-04-5
PubChem ID	37542
InChi Key	IWUCXVSUMQZMFG-AFCXAGJDSA-N
Smiles	O[C@@H]1[C@@H](CO)O[C@@H](N2C=NC(C(N)=O)=N2)[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ribavirin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	24.42	100
	DMSO	24.42	100

Preparing Stock Solutions for Ribavirin

The following data is based on the product molecular weight 244.2.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.10 mL	20.48 mL	40.95 mL
5 mM	0.82 mL	4.10 mL	8.19 mL
10 mM	0.41 mL	2.05 mL	4.10 mL
50 mM	0.08 mL	0.41 mL	0.82 mL

Molarity Calculator

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Reconstitution Calculator

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References for Ribavirin

References are publications that support the biological activity of the product.

Graci and Cameron Mechanisms of action of ribavirin against distinct viruses. Rev.Med.Virol. 2006 PMID: 16287208
Assouline Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with riba. Blood 2009 PMID: 19433856
Tan Inhibition of SARS coronavirus infection in vitro with clinically approved antiviral drugs. Emerg.Infect.Dis. 2004 PMID: 15200845
Kentsis Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap. Proc.Natl.Acad.Sci.U.S.A. 2004 PMID: 15601771

Product Documents for Ribavirin

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Ribavirin, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov