SIS17

Name: SIS17
Brand: Tocris Bioscience
SKU: 7969

Tocris Bioscience, part of Bio-Techne | Catalog # 7969

COA / SDS

Selective HDAC11 inhibitor

Key Product Details

Description:	Selective HDAC11 inhibitor
Chemical Name:	N'-Hexadecylthiophene-2-carbohydrazide
Purity:	≥95% (HPLC)
Molecular Weight:	366.61

View Full Technical Details for SIS17

Technical Data
Citations

Biological Activity for SIS17

SIS17 is a selective HDAC11 inhibitor (IC₅₀ = 0.83 μM). Inhibits demyristoylation of serine hydroxymethyl transferase 2 with no detectable activity at other HDAC subtypes. Combination with Oxaliplatin (Cat. No. 2623) increases cytotoxicity to K562 cells; improves survival of Oxaliplatin-treated 769P cells. Cell permeable.

Technical Data for SIS17

M. Wt	366.61
Formula	C₂₁H₃₈N₂OS
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2374313-54-7
PubChem ID	139035087
InChi Key	HSHXDCVZWHOWCS-UHFFFAOYSA-N
Smiles	O=C(NNCCCCCCCCCCCCCCCC)C=1SC=CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SIS17

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	3.67	10

Preparing Stock Solutions for SIS17

The following data is based on the product molecular weight 366.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.28 mL	136.38 mL	272.77 mL
0.5 mM	5.46 mL	27.28 mL	54.55 mL
1 mM	2.73 mL	13.64 mL	27.28 mL
5 mM	0.55 mL	2.73 mL	5.46 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for SIS17

References are publications that support the biological activity of the product.

Li A pan-cancer analysis identifies HDAC11 as an immunological and prognostic biomarker. FASEB J. 2022 PMID: 35657209
Son Activity-guided design of HDAC11-specific inhibitors. ACS Chem.Biol. 2019 PMID: 31264832