SJ 10542

Name: SJ 10542
Brand: Tocris Bioscience
SKU: 7727

Tocris Bioscience, part of Bio-Techne | Catalog # 7727

COA / SDS

Potent and selective JAK2/3 Degrader (PROTAC®)

Key Product Details

Description:	Potent and selective JAK2/3 Degrader (PROTAC^®)
Chemical Name:	4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(3-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)propyl)benzamide
Purity:	≥97% (HPLC)
Molecular Weight:	818.96

View Full Technical Details for SJ 10542

Technical Data
Citations

Biological Activity for SJ 10542

SJ 10542 is a potent and selective JAK2/3 Degrader (PROTAC^®) (DC₅₀ values are 11 nM and 14 nM; D_max = 92% and 90% for JAK3 and JAK2, respectively); uses a phenyl glutarimide ligand as the cereblon recruiter. Degrades JAK2 in ex vivo cell lines and patient derived xenografts (DC₅₀= <120 nM) and displays high selectivity over GSPT1 and other members of the JAK family.

JAK3 antibody validated for Western Blot also available: Catalog # MAB4699.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from St. Jude Children's Research Hospital

Technical Data for SJ 10542

M. Wt	818.96
Formula	C₄₁H₄₆N₁₂O₅S
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	2789678-92-6
PubChem ID	162679331
InChi Key	WBEBZVDAHMXWJN-UHFFFAOYSA-N
Smiles	O=C(NC1=O)CCC1C2=CC=C(N3CCN(CCCNC(C4=CC=C(NC5=NC6=C(C=CN6)C(C7=CN(C8(CC#N)CN(S(CC)(=O)=O)C8)N=C7)=N5)C=C4)=O)CC3)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SJ 10542

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	40.95	50

Preparing Stock Solutions for SJ 10542

The following data is based on the product molecular weight 818.96.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	2.44 mL	12.21 mL	24.42 mL
2.5 mM	0.49 mL	2.44 mL	4.88 mL
5 mM	0.24 mL	1.22 mL	2.44 mL
25 mM	0.05 mL	0.24 mL	0.49 mL

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References for SJ 10542

References are publications that support the biological activity of the product.

Alcock Development of potent and selective Janus Kinase 2/3 directing PG-PROTACs. ACS Med.Chem.Lett. 2022 PMID: 35300081