Sonidegib

Name: Sonidegib
Brand: Tocris Bioscience
SKU: 7826

Tocris Bioscience, part of Bio-Techne | Catalog # 7826

COA / SDS

Potent Smoothened receptor antagonist

Key Product Details

Description:	Potent Smoothened receptor antagonist
Chemical Name:	rel-N-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	485.51

View Full Technical Details for Sonidegib

Technical Data
Citations

Biological Activity for Sonidegib

Sonidegib is a potent Smoothened (Smo) receptor antagonist (IC₅₀ values are 1.3 nM and 2.5 nM at mouse and human receptors, respectively). Inhibits growth of a variety of tumor types including basal cell carcinoma, small cell lung cancer and medulloblastoma. Sonidegib inhibits Hh pathway in CD34⁺ chronic myeloid leukemia cells; it reduces both the number of cells and self-renewal ability. Brain penetrant and orally bioavailable.

Technical Data for Sonidegib

M. Wt	485.51
Formula	C₂₆H₂₆F₃N₃O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	956697-53-3
InChi Key	VZZJRYRQSPEMTK-CALCHBBNSA-N
Smiles	CC1=C(C2=CC=C(C=C2)OC(F)(F)F)C=CC=C1C(NC3=CN=C(N4C[C@H](O[C@H](C4)C)C)C=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Sonidegib

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	48.55	100

Preparing Stock Solutions for Sonidegib

The following data is based on the product molecular weight 485.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.06 mL	10.30 mL	20.60 mL
5 mM	0.41 mL	2.06 mL	4.12 mL
10 mM	0.21 mL	1.03 mL	2.06 mL
50 mM	0.04 mL	0.21 mL	0.41 mL

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Reconstitution Calculator

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References for Sonidegib

References are publications that support the biological activity of the product.

Irvine Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia. Sci.Rep. 2016 PMID: 27157927
Pan Discovery of NVP-LDE225, a potent and selective smoothened antagonist. ACS Med.Chem.Lett. 2010 PMID: 24900187