SP 141

Name: SP 141
Brand: Tocris Bioscience
SKU: 5332

Tocris Bioscience, part of Bio-Techne | Catalog # 5332

Citations (3)

COA / SDS

High affinity MDM2 inhibitor

Key Product Details

Description:	High affinity MDM2 inhibitor
Chemical Name:	6-Methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole
Purity:	≥98% (HPLC)
Molecular Weight:	324.38

View Full Technical Details for SP 141

Technical Data
Citations

Biological Activity for SP 141

SP 141 is a high affinity MDM2 inhibitor (K_i = 28 nM); directly binds MDM2. SP 141 inhibits MDM2 expression and induces MDM2 autoubiquitination and proteasomal degradation. SP 141 attenuates growth of breast cancer xenograft tumors. SP 141 impairs liposarcoma growth in vitro and in human xenograft models. SP 141 is cell permeable.

Compound Libraries for SP 141

SP 141 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SP 141

M. Wt	324.38
Formula	C₂₂H₁₆N₂O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1253491-42-7
PubChem ID	59620153
InChi Key	AABFWJDLCCDJJN-UHFFFAOYSA-N
Smiles	COC1=CC=C(NC2=C3C=CN=C2C4=CC=CC5=C4C=CC=C5)C3=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SP 141

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	32.44	100
	ethanol	32.44	100

Preparing Stock Solutions for SP 141

The following data is based on the product molecular weight 324.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.08 mL	15.41 mL	30.83 mL
5 mM	0.62 mL	3.08 mL	6.17 mL
10 mM	0.31 mL	1.54 mL	3.08 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

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Reconstitution Calculator

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References for SP 141

References are publications that support the biological activity of the product.

Wang The pyrido[b]indole MDM2 inhibitor SP-141 exerts potent therapeutic effects in breast cancer models. Nat.Commun. 2014 PMID: 25271708