STING Degrader N-Me-SP23

Name: STING Degrader N-Me-SP23
Brand: Tocris Bioscience
SKU: 8054

Tocris Bioscience, part of Bio-Techne | Catalog # 8054

Citations (1)

COA / SDS

Negative control for STING Degrader SP23 (Cat. No. 8053)

Key Product Details

Description:	Negative control for STING Degrader SP23 (Cat. No. 8053)
Chemical Name:	(2E)-N¹-[6-[[2,3-Dihydro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1,3-dioxo-1H-isoindol-4-yl]amino]hexyl]-N⁴-[4-[[(5-nitro-2-furanyl)carbonyl]amino]phenyl]-2-butenediamide
Purity:	≥98% (HPLC)
Molecular Weight:	713.7

View Full Technical Details for STING Degrader N-Me-SP23

Technical Data
Citations

Biological Activity for STING Degrader N-Me-SP23

STING Degrader N-Me-SP23 is a negative control for STING Degrader SP23 (Cat. No. 8053).

Technical Data for STING Degrader N-Me-SP23

M. Wt	713.7
Formula	C₃₅H₃₅N₇O₁₀
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2767427-87-0
InChi Key	GLXVESPMAQKDPG-FOCLMDBBSA-N
Smiles	O=C1C2=C(NCCCCCCNC(/C=C/C(NC3=CC=C(C=C3)NC(C4=CC=C(N(=O)=O)O4)=O)=O)=O)C=CC=C2C(N1C5C(N(C(CC5)=O)C)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for STING Degrader N-Me-SP23

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	71.37	100

Preparing Stock Solutions for STING Degrader N-Me-SP23

The following data is based on the product molecular weight 713.7.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.40 mL	7.01 mL	14.01 mL
5 mM	0.28 mL	1.40 mL	2.80 mL
10 mM	0.14 mL	0.70 mL	1.40 mL
50 mM	0.03 mL	0.14 mL	0.28 mL

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Reconstitution Calculator

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References for STING Degrader N-Me-SP23

References are publications that support the biological activity of the product.

Liu Novel CRBN-recruiting proteolysis-targeting chimeras as degraders of stimulator of interferon genes with in vivo anti- inflammatory efficacy. J.Med.Chem. 2022 PMID: 35452223