SU 3327

Name: SU 3327
Brand: Tocris Bioscience
SKU: 3607

Tocris Bioscience, part of Bio-Techne | Catalog # 3607

Citations (10)

COA / SDS

Selective JNK inhibitor

Key Product Details

Description:	Selective JNK inhibitor
Alternative Names:	Halicin
Chemical Name:	5-[(5-Nitro-2-thiazolyl)thio]-1,3,4thiadiazol-2-amine
Purity:	≥99% (HPLC)
Molecular Weight:	261.3

View Full Technical Details for SU 3327

Technical Data
Citations

Biological Activity for SU 3327

SU 3327 is a selective inhibitor of c-Jun N-terminal kinase (JNK) (IC₅₀ = 0.7 μM). Inhibits the protein-protein interaction between JNK and JIP (IC₅₀ = 239 nM). Displays selectivity over p38 MAPK and Akt. Restores insulin sensitivity in a mouse model of type-2 diabetes. Displays antibiotic activity against a range of bacteria including S.aureus, A.baumanni, C.difficile and M.tuberculosis.

Compound Libraries for SU 3327

SU 3327 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for SU 3327

M. Wt	261.3
Formula	C₅H₃N₅O₂S₃
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	40045-50-9
PubChem ID	11837140
InChi Key	NQQBNZBOOHHVQP-UHFFFAOYSA-N
Smiles	NC2=NN=C(S2)SC1=NC=C([N+]([O-])=O)S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SU 3327

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	26.13	100
	ethanol	2.61	10

Preparing Stock Solutions for SU 3327

The following data is based on the product molecular weight 261.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.83 mL	19.14 mL	38.27 mL
5 mM	0.77 mL	3.83 mL	7.65 mL
10 mM	0.38 mL	1.91 mL	3.83 mL
50 mM	0.08 mL	0.38 mL	0.77 mL

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Reconstitution Calculator

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References for SU 3327

References are publications that support the biological activity of the product.

Higashihira Halicin is effective against staphylococcus aureus biofilms in vitro. Clin.Orthop.Relat.Res. 2022 PMID: 35583504
De Design, synthesis and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-jun N-terminal kinase. J.Med.Chem. 2009 PMID: 19271755