UNC 8732

Name: UNC 8732
Brand: Tocris Bioscience
SKU: 8118

Tocris Bioscience, part of Bio-Techne | Catalog # 8118

COA / SDS

Potent NSD2 Degrader

Key Product Details

Description:	Potent NSD2 Degrader
Chemical Name:	N-[[4-[[[2-(6-Amino-1-oxohexyl)-1,2,3,4-tetrahydro-6-isoquinolinyl]amino]carbonyl]phenyl]methyl]-N-cyclopropyl-3,4-dihydro-3-oxo-2H-1,4-benzoxazine-7-carboxamide trifluoroacetate
Purity:	≥98% (HPLC)
Molecular Weight:	723.75

View Full Technical Details for UNC 8732

Technical Data
Citations

Biological Activity for UNC 8732

UNC 8732 is a potent nuclear receptor binding SET domain-containing 2 (NSD2) Degrader (DC₅₀ = 60 nM; D_max = 97%). NSD2 degradation is driven by the aldehyde metabolite of UNC 8732 in vitro. Recruits FBX022 and SCF complexes for degradation to reduce H3K36me2 levels in cells. Reduces viability and restores glucocorticoid sensitivity of NSD2 p.E1099K mutant ALL cells.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the UNC8732 page on the SGC website.

Technical Data for UNC 8732

M. Wt	723.75
Formula	C₃₅H₃₉N₅O₅.CF₃CO₂H
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2929304-06-1
InChi Key	HFQMCVDNCFEJSF-UHFFFAOYSA-N
Smiles	O=C(C1=CC=C(CN(C2CC2)C(C3=CC=C4NC(COC4=C3)=O)=O)C=C1)NC5=CC=C6C(CCN(C6)C(CCCCCN)=O)=C5.OC(C(F)(F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for UNC 8732

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	72.37	100
	ethanol	72.37	100

Preparing Stock Solutions for UNC 8732

The following data is based on the product molecular weight 723.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.38 mL	6.91 mL	13.82 mL
5 mM	0.28 mL	1.38 mL	2.76 mL
10 mM	0.14 mL	0.69 mL	1.38 mL
50 mM	0.03 mL	0.14 mL	0.28 mL

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Product Documents for UNC 8732

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.