I have seen the recent news reports that indicate this product can be used to cure baldness. I would like to know how I would place an order or use the product to prevent further hair loss or stimulate hair growth.

Name: WAY 316606 hydrochloride
Brand: Tocris Bioscience
SKU: 4767
Rating: 5 (1 reviews)

I'm sorry for your loss but we will not be able to help you. This product is intended for research use only by trained scientific professionals. It must not under any circumstances be used for human, drug, food, cosmetic, agricultural, domestic or any other unapproved consumer purpose. This product has not undergone the rigorous testing, regulatory inspections and approvals that would be required for a pharmaceutical grade product. We cannot legally sell these products for personal use.

WAY 316606 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 4767

(1)

Citations (2)

COA / SDS

Secreted Frizzled-related protein-1 (sFRP-1) inhibitor; increases Wnt signaling

Key Product Details

Description:	Secreted Frizzled-related protein-1 (sFRP-1) inhibitor; increases Wnt signaling
Chemical Name:	5-(Phenylsulfonyl)-N-4-piperidinyl-2-(trifluoromethyl)benzene sulfonamide hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	484.94

View Full Technical Details for WAY 316606 hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for WAY 316606 hydrochloride

WAY 316606 hydrochloride is a secreted Frizzled-Related Protein-1 (sFRP-1) inhibitor (IC₅₀ = 0.65 μM); prevents sFRP-1 from interacting with Wnt and thus increases Wnt signaling. Increases total bone area in a murine calvarial organ culture assay.

We are aware of a study in PLOS Biology where WAY-316606 was found to stimulate hair follicle growth. Please note that WAY-316606 from Tocris is for laboratory research use only, and that we will only sell to established scientific businesses and institutes.

Compound Libraries for WAY 316606 hydrochloride

WAY 316606 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for WAY 316606 hydrochloride

M. Wt	484.94
Formula	C₁₈H₁₉F₃N₂O₄S₂.HCl
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	1781835-02-6
PubChem ID	25186563
InChi Key	YLOYHLUHXQJNGO-UHFFFAOYSA-N
Smiles	O=S(C1=CC=C(C(F)(F)F)C(S(NC3CCNCC3)(=O)=O)=C1)(C2=CC=CC=C2)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for WAY 316606 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	9.7	20

Preparing Stock Solutions for WAY 316606 hydrochloride

The following data is based on the product molecular weight 484.94.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	10.31 mL	51.55 mL	103.11 mL
1 mM	2.06 mL	10.31 mL	20.62 mL
2 mM	1.03 mL	5.16 mL	10.31 mL
10 mM	0.21 mL	1.03 mL	2.06 mL

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References for WAY 316606 hydrochloride

References are publications that support the biological activity of the product.

Moore Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. J.Med.Chem. 2009 PMID: 19072540
Bodine A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation. Bone 2009 PMID: 19254787
Moore Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: part II. Bioorg.Med.Chem. 2010 PMID: 19932972