GDF-8/Myostatin Products
GDF-8/Myostatin is a secreted protein that is expressed in developing and adult skeletal muscle. It controls myoblast proliferation and is a potent negative regulator of skeletal muscle mass. It is upregulated in mechanically-stressed cardiomyocytes and induces the skeletal muscle wasting which is common in heart failure. The GDF-8 propeptide is cleaved from GDF-8 but remains associated and functions as an inhibitor of mature GDF-8. GDF-8 activity can also be inhibited through its association with Follistatin, FLRG, Decorin, or GASP-1. Active GDF-8 signals through a receptor complex containing Activin RIIB and either Activin RIB/ALK-4 or TGF-beta RI/ALK-5.
106 results for "GDF-8/Myostatin" in Products
106 results for "GDF-8/Myostatin" in Products
GDF-8/Myostatin Products
GDF-8/Myostatin is a secreted protein that is expressed in developing and adult skeletal muscle. It controls myoblast proliferation and is a potent negative regulator of skeletal muscle mass. It is upregulated in mechanically-stressed cardiomyocytes and induces the skeletal muscle wasting which is common in heart failure. The GDF-8 propeptide is cleaved from GDF-8 but remains associated and functions as an inhibitor of mature GDF-8. GDF-8 activity can also be inhibited through its association with Follistatin, FLRG, Decorin, or GASP-1. Active GDF-8 signals through a receptor complex containing Activin RIIB and either Activin RIB/ALK-4 or TGF-beta RI/ALK-5.
| Sensitivity: | 5.32 pg/mL |
| Applications: | ELISA |
| Assay Range: | 31.3 - 2,000 pg/mL (Cell Culture Supernates, Tissue Homogenates, Serum, EDTA Plasma, Heparin Plasma) |
| Source: | NS0 |
| Accession #: | O08689 |
| Applications: | BA |
| Reactivity: | Human, Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC, Neut |
| Source: | NS0 |
| Accession #: | O08689.1 |
| Applications: | BA |
For use with catalog number DGDF80
| Applications: | Ctrl |
| Reactivity: | Human, Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC |
| Reactivity: | Mouse |
| Details: | Sheep IgG Polyclonal |
| Applications: | WB, Neut |
| Assay Range: | 31.2 - 2,000 pg/mL |
| Applications: | ELISA |
| Reactivity: | Mouse |
| Details: | Rat IgG2 Monoclonal Clone #RM0243-13F2 |
| Applications: | IHC, WB |
| Reactivity: | Mouse |
| Details: | Rat IgG2b Monoclonal Clone #84231 |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG2B Monoclonal Clone #6E4B2 |
| Applications: | IHC, WB, Flow, ELISA, CyTOF-ready |
| Reactivity: | Mouse |
| Details: | Sheep IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human, Rat |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #3E7 |
| Applications: | WB, ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG2B Monoclonal Clone #6E4E6 |
| Applications: | IHC, WB, ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #2D8 |
| Applications: | WB, ELISA |
| Applications: | Bioactivity, PAGE |
| Applications: | Bioactivity, PAGE |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #OTI7H5 |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG Monoclonal Clone #GDF9/4261 |
| Applications: | WB, ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG Monoclonal Clone #GDF9/4261 |
| Applications: | WB, ELISA |
| Reactivity: | Mouse |
| Details: | Rat IgG2 Monoclonal Clone #RM0243-13F2 |
| Applications: | IHC, WB |
| Reactivity: | Human |
| Details: | Mouse IgG Monoclonal Clone #GDF9/4261 |
| Applications: | WB, ELISA |