17-DMAG hydrochloride

Name: 17-DMAG hydrochloride
Brand: Tocris Bioscience
SKU: 2610

Tocris Bioscience, part of Bio-Techne | Catalog # 2610

Citations (2)

COA / SDS

Water-soluble Hsp90 inhibitor

Discontinued Product

2610 has been discontinued. View all HSP90 Inhibitors products.

Key Product Details

Description:	Water-soluble Hsp90 inhibitor
Alternative Names:	NSC 707545
Chemical Name:	17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	653.21

View Full Technical Details for 17-DMAG hydrochloride

Technical Data
Citations

Biological Activity for 17-DMAG hydrochloride

17-DMAG hydrochloride is a water-soluble analog of 17-AAG (Cat. No. 1515) and geldanamycin (Cat. No. 1368). Binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG (mean GI₅₀ values are 53 and 123 nM for 17-DMAG and 17-AAG respectively).

Licensing Information

Sold with the permission of the NIH, US Patent 6,890,917

Technical Data for 17-DMAG hydrochloride

M. Wt	653.21
Formula	C₃₂H₄₈N₄O₈.HCl
Storage	Desiccate at -20°C
Purity	≥99% (HPLC)
CAS Number	467214-21-7
PubChem ID	9852573
InChi Key	DFSYBWLNYPEFJK-IHLRWNDRSA-N
Smiles	O=C1C(NCCN(C)C)=C(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C/C=C(C)/C2=O)C(C(N2)=C1)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for 17-DMAG hydrochloride

References are publications that support the biological activity of the product.

Smith Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models. Cancer Chemother.Pharmacol. 2005 PMID: 15841378
Dote Inhibition of Hsp90 compromises the DNA damage response to radiation. Cancer Res. 2006 PMID: 16982765
Egorin Pharmacokinetics, tissue distribution, and metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (NSC 707545) in CD2F1 mice and fischer 344 rats. Cancer Chemother.Pharmacol. 2002 PMID: 11855755