Ciliobrevin A

Name: Ciliobrevin A
Brand: Tocris Bioscience
SKU: 4529
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4529

(1)

Citations (10)

COA / SDS

Hedgehog (Hh) pathway antagonist, inhibits ciliogenesis; also inhibits dynein

Key Product Details

Description:	Hedgehog (Hh) pathway antagonist, inhibits ciliogenesis; also inhibits dynein
Alternative Names:	HPI-4
Chemical Name:	2,4-Dichloro-α-(3,4-4-oxo-2(1H)-quinazolinylidene)-β-oxobenzenepropanenitrile
Purity:	≥98% (HPLC)
Molecular Weight:	358.18

View Full Technical Details for Ciliobrevin A

Technical Data
Citations / Reviews (1)

Biological Activity for Ciliobrevin A

Ciliobrevin A is a Hedgehog (Hh) pathway antagonist; blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC₅₀ = 7 μM) downstream of Smo. Perturbs primary cilia formation; inhibits cytoplasmic AAA+ ATPase dynein-dependent microtubule gliding and ATPase activity.

Technical Data for Ciliobrevin A

M. Wt	358.18
Formula	C₁₇H₉Cl₂N₃O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	302803-72-1
PubChem ID	6883982
InChi Key	SESYPWCSIZUIAS-FOWTUZBSSA-N
Smiles	O=C(C1=CC=CC=C1N2)N/C2=C(C(C3=C(Cl)C=C(Cl)C=C3)=O)\C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ciliobrevin A

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	35.82	100

Preparing Stock Solutions for Ciliobrevin A

The following data is based on the product molecular weight 358.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.79 mL	13.96 mL	27.92 mL
5 mM	0.56 mL	2.79 mL	5.58 mL
10 mM	0.28 mL	1.40 mL	2.79 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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References for Ciliobrevin A

References are publications that support the biological activity of the product.

Firestone Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein. Nature 2012 PMID: 22425997
Hyman Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proc.Natl.Acad.Sci.U.S.A. 2009 PMID: 19666565